Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Abiomed, Inc.

Dynamics Research Corporation

Steven F Keller

Karen Keller

Elazer Reuven Edelman

Ahmad El Katerji

Noam Josephy

Brian Yale Chang

Qing Tan

Sonya Sanat Bhavsar

Alexander Ship

Christian Moyer

James Holt

David Hughes

Daniel Strom

Richard Gorzela

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Systems and methods for determining cardiac performance

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Systems and methods for determining cardiac output

A software development tool utilizes an intermediate object modeling language. The structure of the desired program is first described graphically by generating rule diagrams, state diagrams, and object diagrams such as user interface diagrams, event diagrams and other object diagrams. The development tool employs the diagrams to generate a working model of the program expressed in the object modeling language. The working model of the program can be executed without lengthy compiling, and hence program behavior can be quickly observed and tested. Further, the behavior of the working model can be quickly and easily changed by modifying the diagrams until the desired result is achieved. Source code is then generated from the object modeling language and compiled to create the final program.

Software development system with an executable working model in an interpretable intermediate modeling language

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Steven F Keller