Corning Incorporated

Steven Edward DeMartino

Robert Anthony Schaut

John Stephen Peanasky

Santona Pal

Christopher Lee Timmons

Theresa Chang

Andrei Gennadyevich Fadeev

Robert Michael Morena

Dana Craig Bookbinder

Paul Stephen Danielson

Wendell Porter Weeks

Chandan Kumar Saha

Melinda Ann Drake

Natesan Venkataraman

Ronald Luce Verkleeren

James Ernest Webb

Joseph Michael Matusick

Patrick Joseph Cimo

Douglas Miles Noni, Jr

Connor Thomas O'Malley

Kevin Patrick McNelis

Sinue Gomez-Mower

Amber Leigh Tremper

Christy Lynn Chapman

Shivani Rao Polasani

Weirong Jiang

Christie Leigh McCarthy

Jared Seaman Aaldenberg

Bryan James Musk

Eric Lewis Allington

Kristen Dae Waight

Charlene Marie Smith

Zhongzhi Tang

Adam Robert Sarafian

Michael Clement Ruotolo, Jr

Kaveh Adib

Kyle Christopher Hoff

Bruce Gardiner Aitken

Jeffrey Todd Kohli

Joel P Carberry

Michelle Dawn Fabian

Susan Lee Schiefelbein

James Patrick Hamilton

Jennifer Lynn Lyon

Henry Edwin Hagy

Alexander Mikhailovich Streltsov

Joseph Francis Schroeder, Iii

Lisa Ann Lamberson

Sujanto Widjaja

Richard J Miller, Ii

Timothy Michael Gross

Atul Kumar

Thomas Michael Cleary

Cheng-Chung Li

Charles Michael Darcangelo

David Alan Tammaro

Aric Bruce Shorey

Torsten Nath

Fabio Lopes Brandao Salgado

Adam James Ellison

Daniel Warren Hawtof

Lina Ma

Butchi Reddy Vaddi

Michael Edward DeRosa

Nadja Teresia Lönnroth

David Francis Dawson-Elli

John Frederick Bayne

Daniel Duane Strong

Jamie Todd Westbrook

Laura Lee Hluck

Jamie Lynne Morley

Ming-Jun Li

Stephan Lvovich Logunov

William James Miller

Qi Wu

Anping Liu

Xinghua Li

John Christopher Thomas

Brent M Wedding

Michael James Winningham

Gregory Scott Glaesemann

Jeffrey John Domey

Peter Knowles

Michael Albert Joseph, Ii

David Alan Deneka

Aniello Mario Palumbo

Archit Lal

Leonard Thomas Masters

Brian Christopher Sheehan

Kevin William Uhlig

Ulrich W H Neukirch

David Inscho Wilcox

Richard A Nasca

Joseph Fabian Ellison

Paul Steven Danielson

Daniel L Maurey

Alicia Marie Gallagher

Michael Clement Ruotolo

A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dand an average sidewall thickness T, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter Nthat is less than the outer diameter Dof the cylindrical body portion. The average wall thickness Tis less than or equal to 0.85*s, wherein sis a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter dthat is closer to the outer diameter Dthan the outer diameter dof any other standard glass cartridge defined by ISO 13926-1:2004.

Glass containers for storing pharmaceutical compositions

Glass articles with coatings are disclosed herein. According to embodiments, a glass article may include a glass body comprising glass and having a first surface and a second surface opposite the first surface, wherein the first surface is an exterior surface of the glass body. A coating disposed on at least a portion of the exterior surface of the glass body. The coated glass article may have an effective throughput rate greater than or equal to 1.10×R, wherein Ris the effective throughput rate of an uncoated glass article in units of parts per minute (ppm).

Glass articles with low-friction coatings

Disclosed herein are glass containers which may include a glass body comprising an alkali aluminosilicate glass composition having a Class HGA1 hydrolytic resistance when tested according to the ISO 720:1985 testing standard. The glass body may have an interior surface and an exterior surface. A heat-tolerant coating may be bonded to at least a portion of the exterior surface of the glass body. The heat-tolerant coating may have a coefficient of friction of less than about 0.7 and is thermally stable at a temperature of at least 260° C. for 30 minutes. The heat-tolerant coating may comprise a polymer, and the heat-tolerant coating may have a thickness of less than or equal to 100 nm.

Delamination resistant glass containers with heat-tolerant coatings

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

The embodiments described herein relate to chemically and mechanically durable glass compositions and glass articles formed from the same. In embodiments, the glass composition may include 74-78 mol. % SiO; X mol. % AlO, wherein X is 5-7; alkaline earth oxide comprising MgO and CaO, wherein: CaO is 0.1-1.0 mol. %; MgO is 4-7 mol. %; and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %)) is less than or equal to 0.5. The glass composition may further include Y mol. % alkali oxide, wherein the alkali oxide comprises 9-13 mol. % NaO and less than or equal to 0.4 mol. % of a fining agent. The glass composition may be free of boron and compounds of boron.

Glass compositions with improved chemical and mechanical durability

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter dof a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

A glass container comprises a glass body comprising a first region under a compressive stress extending from a surface of the glass body to a depth of compression and a second region extending from the depth of compression into a thickness of the glass body, the second region being under a tensile stress. The glass container also includes a localized compressive stress region having a localized compressive stress extending from the surface to a localized depth of compression within the body. The localized depth of compression is greater than the depth of compression of the first region. The glass container also includes a crack re-direction region extending in a predetermined propagation direction, wherein the crack re-direction region possesses a higher tensile stress than the tensile stress in the second region in a sub-region of the crack re-direction region, the sub-region extending substantially perpendicular to the predetermined propagation direction.

Stress features for crack redirection and protection in glass containers

A strengthened glass container or vessel such as, but not limited to, vials for holding pharmaceutical products or vaccines in a hermetic and/or sterile state. The strengthened glass container undergoes a strengthening process that produces compression at the surface and tension within the container wall. The strengthening process is designed such that the tension within the wall is great enough to ensure catastrophic failure of the container, thus rendering the product unusable, should sterility be compromised by a through-wall crack. The tension is greater than a threshold central tension, above which catastrophic failure of the container is guaranteed, thus eliminating any potential for violation of pharmaceutical integrity.

Glass packaging ensuring container integrity

A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Glass containers with delamination resistance and improved damage tolerance

A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes. A horizontal compression strength of the coated glass package is at least 10% greater than an uncoated glass package and the horizontal compression strength is not reduced by more than 20% after undergoing the depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes and then being abraded. The lubricous coating comprises a polymer.

Glass containers with improved strength and improved damage tolerance

Growing community of inventors

Painted Post, NY, United States of America

Steven Edward DeMartino