Advanced Neuromodulation Systems, Inc.

Knowles Electronics, Inc.

Steven E Boor

Daran DeShazo

Gavin L Rade

Vidhi Desai

Peter V Loeppert

Paris Tsangaris

Frank R Mitchell

Robert C Potter

A system and method are provided that include a power supply having positive and negative terminals. The negative terminal defines a reference ground. First and second electrodes are positioned within a patient and configured to be located proximate to tissue of interest that is associated with a target region. A control circuit is configured to control delivery of current for a therapy between the first and second electrodes. A current regulator (CR) circuit is connected to, and configured to control current flow through, at least the first electrode during delivery of the therapy under direction of the control circuit. A floating power supply is connected across power supply terminals of the CR circuit. The CR circuit and floating power supply are coupled to a floating ground node that is electrically separate from the reference ground.

Method and system with current regulator biased by floating power supply

An implantable medical device (IMD) includes multiple stimulation engines (SEs) for independently stimulating respective electrode sets of a lead system. A voltage multiplier (VM) is configured to generate an adjustable target voltage at an output node. Each stimulation engine includes first switching circuitry to switchably connect an anodic node of the SE to the VM output node and second switching circuitry to switchably connect a cathodic node of the SE to a current sink circuit. Discharge switching circuitry may be disposed between the anodic and cathodic nodes of each SE. A selector and associated digital control logic block are operative to generate control signals for independently controlling respective SEs such that each SE may be activated to stimulate or discharge a corresponding select set of electrodes independently from or in concert with remaining SEs.

Neuromodulation therapy with a multiple stimulation engine system

Embodiments are directed to an implantable medical device comprising therapeutic stimulation circuitry for controlling delivery of a medical therapy to a patient, the therapeutic stimulation circuitry having at least one lead having electrodes for delivering the medical therapy, The implantable medical device further comprises measurement circuitry for determining characteristics of the at least one lead, a processor for controlling the IMD according to executable code, and memory for storing data and executable code, wherein the executable code comprises instructions for causing the processor to receive a plurality of voltage measurements associated with the electrodes, and calculate values for an impedance model of the electrode/tissue interface.

Implantable pulse generator for providing a neurostimulation therapy using complex impedance measurements and methods of operation

A system and method for measuring, monitoring and mitigating EMI interference in an implanted stimulation lead system associated with an IPG. A Kelvin connection scheme operative with a diagnostic circuit is provided for sensing an interference voltage induced at a Kelvin connect electrode of the lead system, wherein the diagnostic circuit is configured to generate one or more control signals for adjusting in substantially real time a common-mode voltage reference provided to supply a biasing voltage to the IPG circuitry.

Diagnostic circuitry for monitoring and mitigating electromagnetic interference (EMI) in an implantable pulse generator

An implantable medical device (IMD) includes multiple stimulation engines for independently stimulating respective electrode sets of a lead system while avoiding collisions and/or channel contention during stimulation delivery. A first voltage multiplier is configured to generate an adjustable target voltage having sufficient headroom at an output node that is commonly coupled to anodic nodes of respective stimulation engines. Each stimulation engine includes a secondary voltage multiplier to drive the respective anode and a current regulator powered by a floating voltage supply, wherein the current regulator is coupled to a cathodic node and configured to control how much stimulation current is pulled from the patient tissue.

Implantable pulse generator with multiple stimulation engines

A neurostimulation (NS) system and method are provided. The NS system includes an array of electrodes positioned within a patient. The array of electrodes includes an active electrode. The active electrode is configured to be a cathode electrode located proximate to neural tissue of interest that is associated with a target region. The NS system includes an anode electrode and an electromagnetic interference (EMI) antenna. A control circuit is configured to control delivery of a NS therapy during a therapy delivery interval. The NS therapy is to be delivered between the anode electrode and the active electrode. The NS system develops a residual voltage between the anode electrode and the active electrode over the therapy delivery interval. A current regulator (CR) circuit is connected to the cathode electrode. The CR circuit is configured to control current flow through the cathode electrodes. During a discharge operation, the control circuit is configured to manage the CR circuit to control a discharge current flow over the discharge operation to discharge the residual voltage after therapy delivery in a manner that follows an actively emulated passive discharge (AEPD) profile. During the discharge operation, the CR circuit is connected to the inactive electrode. The CR circuit receives, as a first input, an EMI feedback signal from the EMI antenna. The CR circuit is configured to regulate the discharge current flow through the active electrode based on the EMI feedback signal, to maintain the AEPD profile over the discharge operation while in a presence of an EMI event.

Neurostimulation method and system for active emulation of passive discharge in presence of MRI/EMI interference

An implantable medical device (IMD) includes an adjustable capacitive voltage multiplier (CVM) that is responsive to diagnostic circuitry configured to provide control signals within a single stimulation current pulse for adjusting the voltage output applied to an electrode of the IMD's lead system. A control counter is coupled to the diagnostic circuitry for incrementing or decrementing an N-bit counter output signal operative to reconfigure a charge pump arrangement of the CVM so as to facilitate an adjusted voltage output.

Capacitive voltage multiplier for providing adjustable control during a stimulation pulse

A system and method for measuring and monitoring charge states of one or more electrodes of an implanted stimulation lead system associated with an IPG. A Kelvin connection scheme operative with a switching circuit is provided for coupling select electrode terminals disposed in a Kelvin connection measurement loop in a switchable manner to sense and reference inputs of an analog-to-digital converter (ADC) configured as at least part of diagnostic circuitry for the IPG.

Diagnostic circuitry for monitoring charge states of electrodes of a lead system associated with an implantable pulse generator

The present disclosure provides systems and methods for circuitry for an implantable pulse generator (IPG) of a neurostimulation system. The circuitry includes at least one anode node, at least one cathode node, a plurality of switching circuits, each switching circuit coupled to the at least one anode node and the at least one cathode node, and a plurality of output channels, each output channel coupled between an associated switching circuit and at least one electrode. The circuitry further includes a first DC blocking capacitor coupled between the at least one anode node and the plurality of switching circuits, a second DC blocking capacitor coupled between the at least one cathode node and the plurality of switching circuits. The circuitry further includes mitigation circuitry operable to limit DC leakage from the plurality of switching circuits through the plurality of output channels.

Systems and methods for DC protection in implantable pulse generators

The present disclosure provides systems and methods for an output architecture for an implantable pulse generator of a neurostimulation system. The output architecture includes a power supply, a plurality of outputs, a global source current regulator coupled to the power supply and operable to source current from the power supply to the plurality of outputs through a plurality of source current branches, a global sink current regulator operable to sink current from the plurality of outputs to ground through a plurality of sink current branches, a current source branch selector operable to select, for each of the plurality of outputs, an amount of current sourced from the plurality of source current branches, and a current sink branch selector operable to select, for each of the plurality of outputs, an amount of current sunk to the plurality of sink current branches.

Systems and methods for output channel architectures in implantable pulse generators

A system and method for extracting ETI load parametric data relative to one or more electrodes of an implanted stimulation lead system associated with an IPG. A Kelvin connection scheme is provided for measuring induced voltages present at stimulated electrodes during a stimulation ramping sequence, which may be used for determining the ETI parametric data using a number of techniques, including, without limitation, a waveform analysis.

Parametric characterization of an implanted lead system associated with an implantable pulse generator

A neurostimulation (NS) system and method are provided. The system includes a power supply having positive and negative terminals. The negative terminal defines a reference ground. An array of electrodes includes first and second active electrodes for delivering stimulation therapy configured to be located proximate to neural tissue of interest that is associated with a target region. A control circuit is configured to control delivery of stimulation current for a NS therapy between the first and second electrodes. A current regulator (CR) circuit is connected to, and configured to control current flow through, at least the first electrode during delivery of the stimulation therapy under direction of the control circuit. A floating power supply is connected across power supply terminals of the CR circuit. The CR circuit and floating power supply are coupled to a floating ground node that is electrically separate from the reference ground.

Neurostimulation method and system with current regulator biased by floating power supply

In one embodiment, an implantable pulse generator (IPG) for providing a neurostimulation therapy, comprises: pulse generation circuitry and pulse delivery circuitry for controlling generation and delivery of electrical pulses to a patient using one or more electrodes of a stimulation lead; measurement circuitry for determining characteristics of one or more electrodes selected for delivery of electrical pulses; and a processor for controlling the IPG according to executable code; wherein the IPG is adapted to calculate values for an impedance model of the one or more selected electrodes using the determined plurality of voltage measurements and to adjust current levels for the exponentially decreasing current pattern based on the calculated values for the impedance mode.

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Lombard, IL, United States of America

Steven E Boor