Micromass UK Limited

Waters Technologies Corporation

Micromss UK Limited

Miromass UK Limited

Steven Derek Pringle

Jason Lee Wildgoose

Kevin Giles

Keith George Richardson

Martin Raymond Green

Emrys Jones

Zoltan Takats

Michael Raymond Morris

Robert Harold Bateman

Daniel Szalay

Lajos Godorhazy

Daniel Simon

Julia Balog

Jeffery Mark Brown

Tamas Karancsi

Daniel James Kenny

David John Langridge

James Ian Langridge

Ian Sinclair

Farnoush Salarzaei

Frances Bolt

John Brian Hoyes

Anthony James Gilbert

Stephen O'Brien

Kevin R Howes

Tamás Karancsi

Anthony Hesse

Pamela Pruski

David Alan MacIntyre

Richard Stearns

Phillip Robert Bennett

Zoltán Takáts

Richard Ellson

Lars Majlof

Ian David Trivett

Richard Denny

Richard Chapman

Michael McCullagh

Alvin Chua

Jeffrey Goshawk

Mike Morris

Stephen Smith

Nicholas Tomczyk

Steve Smith

Matt Henderson

Joseph D Michienzi

David Gordon

Wade P Leveille

Paul Robert Murray

Jeffrey Musacchio

John Skilling

Jeremy Kirk Nicholson

Jeffrey Mark Brown

Garry Michael Scott

Dániel Szalay

Jakub Ujma

Gregory T Roman

Steve Bajic

Stephen Hattan

Darren Hewitt

Martin Palmer

Eleanor Riches

Jason Lee Woldgoose

Kevil Giles

James Kinross

Zoltan Takáts

Dániel Simon

Lajos Gödörhazy

Júlia Balog

Keith Richardson

A method of selecting ions comprises selecting ions corresponding to a target ion of interest by separating analyte ions according to their ion mobility, isolating first ions of the analyte ions, separating the first ions according to their ion mobility, and isolating second ions of the first ions. Preferably, the separation is accomplished by using a cyclic or closed-loop separator.

Method of selecting ions by ion mobility separation and isolation of ions

An analytical device for analysing ions is provided comprising a separatorfor separating ions according to a physico-chemical property and an interfacecomprising one or more ion guides. A quadrupole rod set mass filteris arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separatorthrough the interfacewith a first transit time t1 and

Optimized ion mobility separation timescales for targeted ions

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

Tissue analysis by mass spectrometry or ion mobility spectrometry

A method is disclosed comprising: trapping ions in an ion trap (); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

Separating ions in an ion trap

A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

Sprayer assembly for DESI applications

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

Spectrometric analysis of microbes

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

Cell population analysis

A method of producing ions from a sample is disclosed. The method comprises directing a spray of droplets onto a sample, and causing droplets comprising analyte from the sample to impact upon a surface so as to generate analyte ions.

Method of producing ions using spray droplets onto a sample

A method of ion mobility and/or mass spectrometry is disclosed in which the ion mobility and/or mass to charge ratio of an ion is determined using an algorithm or relationship that relates the transit time or average ion velocity of the ion through an ion separation device in which one or more time-varying electric field is used to separate ions passing therethrough to one or more parameters for the device, the mass to charge ratio of the ion and the ion mobility of the ion.

Mobility and mass measurement using time-varying electric fields

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

Spectrometric analysis

A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T) one or more times so as to form one or more second groups of ions, wherein the second period of time (T) is less that the first period of time (T), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

Trap fill time dynamic range enhancment

A method of mass and/or ion mobility spectrometry is disclosed that includes ionising analyte from a sample so as to generate a plurality of ions, separating precursor ions from first fragment and/or other ions of the plurality of ions, fragmenting or reacting at least some of the precursor ions using a fragmentation, reaction or collision device so as to generate second fragment ions, and then analysing at least some ions that emerge from the fragmentation, reaction or collision device. The sample is classified and/or identified based on the analysis of the second fragment ions.

Utilising fragmentation in analysis of lipids and other compound classes

A method of filtering ions according to their ion mobility using a device is disclosed, the method comprising a plurality of electrodes and one or more voltage source(s) arranged and adapted to apply voltages to the plurality of electrodes, the method comprising, generating using the one or more voltage source(s) one or more local separation region(s), wherein ions can be separated within each local separation region according to their ion mobility, and moving each local separation region axially along the device with a certain velocity such that, for each local separation region, ions having a value of their ion mobility falling within a selected range are transmitted axially along the device with that local separation region whereas ions having higher and/or lower ion mobility falling outside that range escape the local separation region, wherein any ions that escape the local separation region(s) are removed from within the device and/or otherwise kept apart from those ions falling within the selected range(s).

Ion filtering devices

Growing community of inventors

Darwen, United Kingdom

Steven Derek Pringle