Vertex Pharmaceuticals, Inc.

Other

Steven David Stone

Michael Aaron Brodney

Jingrong Cao

Jon H Come

John E Cochran

Suganthini S Nanthakumar

Haoxuan Wang

Leslie A Dakin

Timothy J Senter

Brad D Maxwell

Akira Joseph Shimizu

Elena Dolgikh

Samantha Angle

Jun Myun Ahn

Jessica Howard Olsen

Hardwin O'Dowd

Bruce D Blevins

Hardwin O′dowd

The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Inhibitors of APOL1 and methods of using same

A troll line depressor includes a pair of triangular wings with a dihedral angle of about 100 degrees therebetween. A rigid bridle connected between the upper and lower ends of the depressor provides a sliding connection for a ring at the end of a towing line, so that the depressor normally develops hydrodynanmic forces to depress the end of the towing line, but can tilt backward to an inoperative position when a fish strikes, or forward to an inoperative position if the depressor engages river bottom debris.

Trolling line depressor

Growing community of inventors

Quincy, MA, United States of America

Steven David Stone