Research, Incorporated

Steven D Wyrick

Iris H Hall

James M Chapman, Jr

Agnes Dubey

A compound having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy is disclosed. These compounds demonstrate utility as hypolipidemic agents. The present invention is also directed to a process for controlling lipidemia in mammals comprising treating mammals with a lipidemia controlling effective amount of the above-defined compound. Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising the above compound and a pharmaceutically acceptable carrier therefor.

N,N-diaminophthalamides

A compound having the structural formula ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 carbalkoxyalkyl or phenyl substituted with C.sub.1 -C.sub.3 alkyl or halogen; R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R.sup.3 and R.sup.4 are the same or different and are hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen with the provisos that if R.sup.2, R.sup.3 and R.sup.4 are hydrogen, then R.sup.1 is not methyl, n-propyl or phenyl substituted with methyl in the ortho or para position; if R.sup.1, R.sup.2 and R.sup.3 are hydrogen then R.sup.4 is not hydrogen, methyl or methoxy; and if R.sup.1 and R.sup.2 are both n-propyl or n-butyl then R.sup.3 and R.sup.4 are not both hydrogen. These compounds demonstrate utility as hypolipidemic agents. The present invention is also directed to a process for controlling hyperlipidemia in mammals comprising treating mammals with a hyperlipidemia controlling effective amount of a compound having the above-identified structural formula wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 carboxyalkyl, C.sub.2 -C.sub.6 carbalkoxyalkyl, phenyl or phenyl substituted with C.sub.1 -C.sub.3 alkyl or halogen; R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R.sup.3 and R.sup.4 are the same or different and are hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen. Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising a compound having the above structural formula wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 carboxyalkyl, C.sub.2 -C.sub.6 carbalkoxyalkyl, phenyl or phenyl substituted with C.sub.1 -C.sub.3 alkyl or halogen; R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R.sup.3 and R.sup.4 are the same or different and are hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen and a pharmaceutically acceptable carrier therefor.

2,3-dihydrophthalazine-1,4-diones

A process for controlling hyperlipidemia in mammals is disclosed. In this process a hyperlipidemia controlling effective amount of a compound having structural formula: ##STR1## where R.sup.1 is hydrogen, oxo, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; R.sup.2 is hydrogen or oxo; and R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 carboxyalkyl, phenyl, benzyl or phenyl substituted with C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkanoyl, C.sub.1 -C.sub.6 alkoxy or halo is applied to mammals. A pharmaceutical composition comprising the above class of compounds having the meanings given herein and a pharmaceutical carrier therefor is also taught.

Process for controlling hyperlipidemia

This invention relates to novel N-benzoylsulfamates, N-benzylsulfamates and benzylsulfonamides and pharmacologically acceptable salts thereof, a method for lowering serum levels in mammals by administration of said compounds, and pharmaceutical compositions thereof.

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Durham, NC, United States of America

Steven D Wyrick