The State University of New York

The Penn State Research Foundation

Quadrant Biosciences Inc.

Other

Steven D Hicks

Frank A Middleton

Richard Uhlig

Tim Arnst

Alexander Rajan

A method for evaluating or monitoring metabolic effects of exercise or injury by detecting and/or quantifying microR-NAs in saliva. Compositions and methods of treatment based on detection of microRNAs.

Method for monitoring metabolism before and after exercise or injury using salivary micro-RNAs

Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva. Methods for controlled and normalized comparisons of salivary miRNA concentration levels are further provided. Assay kits comprising salivary miRNAs, probes and/or primers for detecting salivary miRNAs are also provided.

Analysis and prediction of traumatic brain injury and concussion symptoms

This application provides methods to differentiate between subjects with autism spectrum disorder (ASD) and typically developing (TD) or developmentally delayed (DD) subjects using miRNA and/or microbiome levels detected in saliva samples and patient information. The method can be used to monitor the progress of ASD and guide its treatment. RNA-seq, qPCR, or other methods determine counts and abundance of miRNA or microbiomes. MicroRNA and/or microbiome sequencing data are refined by normalization to expression levels or abundance of time-invariant miRNAs and/or microbial RN As to control for time of sample collection or to compensate for circadian fluctuations in these levels. Multivariate logistic regression and nonlinear classification techniques are further used to select a panel of miRNAs and microbiomes that accurately differentiate between subjects with ASD, DD, and TD in subjects with an unknown ASD status. These panels of miRNAs and microbiomes may be developed into a RNA assay kit.

Analysis of autism spectrum disorder

Electrical switch lockout devices for selectively maintaining a position of an electrical switch on an electrical switch base are described. The electrical switch lockout devices include a base adapter configured to be fitted around the electrical switch base, a housing that is moveable between an engaged position and a disengaged position, and a locking mechanism. The housing includes walls, an opening on one side of the housing, a first lateral lip disposed on a first edge of the opening, and a second lateral lip disposed a second edge of the opening. The first lateral lip and the second lateral lip are configured to engage and disengage with the base adapter in the engaged and disengaged positions, respectively.

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Hershey, PA, United States of America

Steven D Hicks