Smithkline Beecham Corporation

Steven Coulton

Roderick Alan Porter

Amanda Johns

Christopher Norbert Johnson

Geoffrey Stemp

Eric Hunt

Clive Leslie Branch

Kevin Thewlis

Jeremy David Hinks

Mervyn Thompson

George Burton

Stephen Frederick Moss

Stephen Christopher Martin Fell

Alfred John Eglington

Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.

N-aroyl cyclic amines

This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.

Ethylene diamine derivatives and their use as orexin-receptor antagonists

This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein:

A compound of formula (I):whereinRis hydrogen, optionally substituted (C)alkyl or optionally substituted aryl;Ris hydrogen, optionally substituted (C)alkyl or optionally substituted aryl; orRand Rtogether form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms;Ris (C)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group;Ris hydrogen or methyl; and&#x2014;CORis carboxy or a carboxylate anion or the group Ris a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I). Compounds of formula (I) which include pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof have a broad spectrum of anti-bacterial activity and show good stability towards DHP-1.

2-(pyrazol-3-yl)carbapenem derivatives

Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists

Phenyl urea and phenyl thiourea derivatives

Novel isoquinoline derivatives and methods of using them to treat various neurological indications are disclosed.

Isoquinoline derivatives and their therapeutical use

The present invention relates to substituted isoquinoline derivatives and their use as anticonvulsants.

Substituted isoquinoline derivatives and their use as anticonvulsants

Disclosed are a carbapenem compound represented by formula (I) and processes to its preparation.

Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids, a process for their preparation, pharmaceutical compositions comprising said compounds and a method of using them to treat bacterial infections.

Growing community of inventors

Harlow, United Kingdom

Steven Coulton