Leland Stanford Junior University

Visby Medical, Inc.

Click Diagnostics, Inc.

Bio-medical Engineering (hk) Limited

Other

Research Corporation Technologies, Inc.

Thorlabs Gmbh

Steven Chu

Gregory Loney

David Swenson

Adam De La Zerda

Brian Ciopyk

Boris Andreyev

Victor Briones

Helen Huang

Jesus Ching

Keith Edward Moravick

Colin Kelly

Yilei Li

Chung-Kwong Yeung

Jonathan Hong

Yi Cui

Wing Fai Lam

Kai Yan

William Swann

Noah Yuzo Toyonaga

Alex Cable

Jun Li

Mark A Kasevich

Carl Weiman

James Jiang

Guangyuan Zheng

James A Spudich

Chunte Peng

Stephen J Kron

Jeffrey Finer

Wenling Chan

Robert Simmons

Tin Chak Johnson Pang

Hon Chung Chung

Sanjeevi Sivasankar

Charles M Schroeder

Eric S G Shaqfeh

Hazen P Babcock

Vladan Vuletic

Yunxiang Zhang

Qian Liu

An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.

Printed circuit board heater for an amplification module

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Devices and methods for molecular diagnostic testing

This disclosure relates to combined frequency and angle compounding for speckle reduction in ultrasound imaging. Such combined frequency and angle compounding can result in a multiplicative speckle reduction compared to using either frequency compounding or angle compounding alone. Compounding methods of this disclosure can make use of the full aperture of the ultrasound probe when acquiring individual images, hence there can be no compromise in resolution. In disclosed embodiments, ultrasound images can be obtained while an ultrasound probe is moving and the relative position and orientation of the ultrasound images can be determined from a measurement of the position and orientation of the ultrasound probe. Certain embodiments can correct for the movement and distortion of an object being imaged during the image acquisition.

Combined frequency and angle compounding for speckle reduction in ultrasound imaging

This disclosure relates to ultrasound imaging with reduced speckle. Ultrasound imaging with frequency compounding and angle compounding is disclosed. Techniques are disclosed to make ultrasound imaging with frequency and angle compounding more robust. One such technique is non-rigid image registration to align ultrasound images for angle compounding. Another disclosed technique includes selecting a subset of ultrasound images for non-rigid ultrasound image registration.

Compounding and non-rigid image registration for ultrasound speckle reduction

An upconversion single molecule probe is provided that includes a core having a nanoparticle seed crystal, where the nanoparticle seed crystal is an upconversion seed crystal, a first shell enveloping the core, and a second shell enveloping the first shell.

Ultrabright lanthanide-doped nanoparticles

Nonlinear ultrasound imaging systems and methods are disclose. In one aspect, a nonlinear ultrasound imaging system includes a first transducer configured to transmit a first ultrasound signal along a scan line, a second transducer configured to sweep a second ultrasound signal along the scan line such that the first and second ultrasound signals intersect at a plurality of voxels, and a third transducer configured to receive echoes associated with interactions of the first and second ultrasound signals at the plurality of voxels. The nonlinear ultrasound imaging system further includes a processor configured to generate an ultrasound image based on the echoes.

Ultrasound imaging by nonlinear localization

Ultrasound imaging systems and methods with frequency (spectral) compounding for speckle reduction are disclosed. In one aspect, an ultrasound imaging system includes a transducer probe with interleaved transmit and receive arrays. The system may utilize ultrasound pulses having an optimized time-bandwidth product. In one aspect, a transducer probe with separate transmit and receive elements can enable transmission and reception of multiple ultrasound pulses, each centered at a different frequency, during the time of one A-scan. Thus, such a system can capture multiple independent speckle images without reducing overall B-mode framerate. In another aspect, the system may transmit a broadband pulse and may obtain separate speckle images by filtering the received echo using multiple spectral filters. The system may compound multiple images captured at different frequencies to provide speckle reduction. The ultrasound imaging system further includes a processor configured to generate an ultrasound image based on the echoes.

Ultrasound imaging with spectral compounding for speckle reduction

Example embodiments relate to endoscopic systems. The system includes an outer assembly and main assembly. The outer assembly may include proximal and distal ends and outer anchor assembly. The outer anchor assembly may include a first expandable member and first outer pressure opening. The first expandable member may expand radially outwards. The main assembly may include proximal and distal ends and a navigation assembly. The navigation assembly may include an instrument, second expandable member, bendable section, extendible section, and first pressure opening. The extendible section may include proximal and distal ends. The proximal end of the extendible section may be secured in position relative to the distal end of the outer assembly. The extendible section may be configurable to extend and contract. The first main pressure opening may be configurable to apply a negative pressure.

Endoscopic systems, devices and methods

Systems and methods for automated steering control of a robotic endoscope, e.g., a colonoscope, are provided. The control system may comprise: a) a first image sensor configured to capture a first input data stream comprising a series of two or more images of a lumen; and b) one or more processors that are individually or collectively configured to generate a steering control output signal based on an analysis of data derived from the first input data stream using a machine learning architecture, wherein the steering control output signal adapts to changes in the data of the first input data stream in real time.

Automated steering systems and methods for a robotic endoscope

Growing community of inventors

Menlo Park, CA, United States of America

Steven Chu