Pfizer Corporation

Amgen Fremont Inc.

Other

Abgenix, Inc.

Steven Christopher Gilman

Jose Corvalan

C Geoffrey Davis

Douglas Charles Hanson

Eileen Elliott Mueller

Jeffrey Herbert Hanke

Mark Joseph Neveu

Jose Ramon Corvalan

Eileen Elliot Mueller

José Ramon Corvalan

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

Human monoclonal antibodies to CTLA-4

Methods of treating cancer with human monoclonal antibodies to CTLA-4

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

Nucleic acids encoding human monoclonal antibodies to CTLA-4

Methods and host cells for producing human monoclonal antibodies to CTLA-4

Methods for expressing and recovering human monoclonal antibodies to CTLA-4

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Growing community of inventors

Cambridge, MA, United States of America

Steven Christopher Gilman