Eastman-kodak Company

Johnson & Johnson Clinical Diagnostics, Inc.

Steven C Switalski

Hsue-Yang Liu

Allan Wexler

Grace Ann Bennett

Kimberly S Lindner

Michael Alan Marcus

Thomas R Kissel

David Scott Uerz

James R Sandifer

Alan J Lowne

Syamal K Ghosh

Paul B Merkel

Jeffrey L Helfer

Kam Chuen Ng

Bradley K Coltrain

Joseph F Revelli, Jr

Eric T Prince

Donald J Majka

An interfacial electric field intensity of a surface is measured by covalently binding a monolayer of a voltage sensitive chromophore to the surface and irradiating it with actinic radiation while it is in contact with a liquid and measuring a first fluorescence emission spectrum. A solution of the voltage sensitive chromophore dissolved in a sample of the liquid is also irradiated with actinic radiation and a second fluorescence emission spectrum is measured. The first and second fluorescence emission spectra are compared to determine the interfacial electric field intensity.

Method for measuring solid-liquid interfacial electric field

A characteristic difference between first and second liquids is measured using a surface having a monolayer of a voltage sensitive chromophore that is covalently bound to the surface. The first liquid is brought into contact with the surface and it is irradiated with actinic radiation to measure a first fluorescence emission spectrum. The second liquid is also brought into contact with the surface and it is irradiated with actinic radiation to measure a second fluorescence emission spectrum. The first and second fluorescence emission spectra are compared to characterize a difference between the first and second fluids.

Method for determining a characteristics difference between fluids

A characteristic of a liquid is measured by providing a surface having a monolayer of a voltage sensitive chromophore that is covalently bound to the surface. The liquid is brought into contact with the surface and it is irradiated with actinic radiation to measure a first fluorescence emission spectrum. A solution of the voltage sensitive chromophore dissolved in a sample of the liquid is also irradiated with actinic radiation and a second fluorescence emission spectrum is measured. The first and second fluorescence emission spectra are compared to determine the characteristic of the liquid.

Method for characterizing a liquid

A method of measuring the thickness or the rate of change of thickness of a layer as the layer is being formed on a substrate, includes illuminating the layer through the substrate with low coherence light that transmits through the layer; collecting a portion of the reflected light from each optical interface of the substrate and layer with a low coherence interferometer; and, calculating the thickness or the rate of change of thickness of the layer according to the obtained interferometric data.

Measuring layer thickness or composition changes

A method of using a compacted pellet having uniform blended mixture with at least first and second different organic components that sublime at temperatures Tand Trespectively, wherein Trepresents the temperature of the first organic material with the lowest sublimation temperature and Trepresents the temperature of the second organic material with the highest sublimation temperature, to form an organic layer having a uniform blended mixture of the organic components, includes providing a compacted pellet, having a top and bottom surface, into a boat having an open top surface wherein the compacted pellet conforms to the interior of the boat; and applying heat to the top of the compacted pellet to cause the deposition of a uniform blended mixture of the organic components to form an organic layer.

Organic materials for an evaporation source

An on-line method for detecting particle size of a liquid during a process in which there is not a correlation between low absorbance with small particle size, the method comprises the steps of measuring a plurality of reference particle sizes each associated with a particular near infrared diffuse reflectance spectrum for creating a reference infrared diffuse reflectance spectrum having high absorbance with small particle size; measuring on-line a near infrared diffuse reflectance spectrum of the liquid during the process; and determining the particle size of the on-line liquid based on correlating the on-line-measured particle size with the reference near infrared diffuse reflectance spectrum.

On-line method for detecting particle size during a milling process

There is disclosed a slide test element and method of assay that allows for detection of analytes in biological liquids without the use of any detection reagents. The method uses NIR spectroscopy and a test element comprising a support, and a substantially constant light-path defining layer comprising a diffusely-reflecting material that is a) sufficiently porous in all directions as to allow a liquid to spread uniformly in all directions, and b) homogeneously reflects at least 95% of NIR radiation.

Method for quantitative NIR spectroscopic analysis

Test element for quantitative NIR spectroscopic analysis

A postacquired spectrophotometer, for use with a sample and reference. The spectrophotometer has a filter unit, defining an axis of movement, and pluralities of designated sites and dark sites disposed in uniform relation to the axis. The designated and dark sites are disposed in alternation. Alternating designated sites have apertures and filters covering the apertures. Further, a main member, coaxial with the filter unit, has sample and reference beam paths, which are intersected by the sites. The main member has disposed, in operative relation to the actuators, an actuator sensor, which generates an integration actuator signal upon alignment with each integration actuator and a clamping actuator signal upon alignment with each clamping actuator. Moreover, a drive continuously moves the filter unit relative to the axis and beam paths. Further, a light distribution system directs light separately from the sample and reference to respective beam paths, and then to a detector, which produces a detector signal responsive to light received. Finally, means for processing the signals is provided, including a clamping circuit, integrators, and a demultiplexer.

Postacquired spectrophotometers

A spectrophotometer is described, comprising a single light source, a single detector, optics for dually and alternatively reading a sample and a reference, and only one moving part. That moving part is a chopper containing multiple pass-through apertures, each filled with a unique bandpass filter to select wavelengths to specifically illuminate the sample or reference. To inform the spectrophotometer whether and when it is reading the sample or the reference, trigger means are provided in at least twice the number of the pass-through apertures.

Spectrophotometer having means for simultaneous modulation, switching

A waveguide optical device having a guide member for propagation of light in a longitudinal direction. The guide member has upper and lower boundaries. A mass of birefringent material is disposed proximal to the guide member. The birefringent material has molecular dipoles subject to alignment by an imposed electrical field. The birefringent mass is overlapped by the optical field of the propagated light. An upper electrode is disposed in spaced relation to the birefringent mass. A lower electrode is disposed in spaced relation to the guide member. The electrodes have the capability of imposing an alternating current voltage across the birefringent mass to rotate the molecular dipoles of the birefringent mass in a plane defined by the normal to the guide member and the propagation vector of the light. The boundaries and the electrodes define an upper isolation zone between the upper electrode and the upper boundary, a guide path between the boundaries, and a lower isolation zone between the lower boundary and the lower electrode. The guide path has an effective index of refraction greater than the effective indexes of refraction of the isolation zones.

Planar waveguide liquid crystal variable retarder

There are disclosed an instrument and method for using near IR to discriminate between healthy and diseased tissue, using, e.g., a catheter and a spectrophotometer. Near IR is passed at certain wavelengths to suspected tissue, and reflected light is analyzed to determine the absorbance, and preferably the second derivative thereof. From identification of the absorption spectra of known diseased and known healthy tissue, a relation has been established to determine the following correlation equation for determining the predictive value of y:

Near infrared diagnostic method and instrument

Silicic acid heteropolycondensates containing a luminescent compound, whose luminescence is quenchable by oxygen, form suitable sensors for measuring oxygen content in an oxygen-containing gaseous, liquid, or solid sample.

Growing community of inventors

Rochester, NY, United States of America

Steven C Switalski