Janssen Pharmaceutica Nv

Steven C Pomerantz

Jinquan Luo

Sheng-Jiun Wu

Alexey Teplyakov

Ricardo Attar

John Wheeler

Susan H Tam

Francois Gaudet

Yingzhe Li

Ronan McDaid

Jennifer F Nemeth

Benjamin C Harman

Ronan Mcdaid

Provided herein are antibodies that immunospecifically bind to CD123. Also described are related polynucleotides capable of encoding the provided CD123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor CD123-expressing cancer progression, regression, or stability; to determine whether or not a patient should be treated for cancer; or to determine whether or not a subject is afflicted with CD123-expressing cancer and thus may be amenable to treatment with a CD123-specific anti-cancer therapeutic, such as the multispecific antibodies against CD123 and CD3 described herein.

CD123 binding agents and uses thereof

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Huntingdon Valley, PA, United States of America

Steven C Pomerantz