Human Genome Sciences, Inc.

Cambridge Antibody Technology Limited

Steven C Barash

Gil H Choi

Craig A Rosen

Charles A Kunsch

Michael R Fannon

Patrick J Dillon

Brian A Dougherty

Steven M Ruben

Tristan J Vaughan

David M Hilbert

Patrick J Dillion

Patrick S Dillon

Gil A Choi

Brian Dougherty

The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

Antibodies that immunospecifically bind to B lymphocyte stimulator protein

The present invention provides polynucleotide sequences of the genome of, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

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The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines

The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP042 polynucleotides

The present invention relates to novel vaccines for the prevention or attenuation of infection by. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides

The present invention provides polynucleotide sequences of the genome of , polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Staphylococcus aureus polynucleotides and sequences

The present invention relates to novel vaccines for the prevention or attenuation of infection by . The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of . Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

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Rockville, MD, United States of America

Steven C Barash