Novartis Ag

Sirenas LLC

Steven Bruce Cohen

Thomas Huber

Tinya Abrams

Kathy Miller

Kathrin Ulrike Tissot-Daguette

Siew Ho Schleyer

Catrin Finner

Bryan Junn Lee

Jacob Neal Beverage

Ippei Usui

Venkat Rami Reddy Macherla

Eduardo Esquenazi

Christie P Fanton

Jean-Michel Rene Rondeau

Bernhard Hubert Geierstanger

Weijia Ou

William Mallet

Jun Li

Matthew John Meyer

Dylan L Daniel

Alexander Wayne Schammel

Clemens Dürr

Jason Damiano

Katherine Rendahl

Chung-Mao Pan

Elizabeth Paige Stout

Farhana Barmare

Daniel Menezes

Venkata Rami Reddy Macherla

Sarah Rue

David Langdon Yowe

Oliver Booth Vining

Clemens DÜRR

Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

Cyclic peptide analogs and conjugates thereof

The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

CKIT antibody drug conjugates

Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Anti-cancer compounds and conjugates thereof

This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Antibody drug conjugates

cKIT antibody drug conjugates

Growing community of inventors

San Diego, CA, United States of America

Steven Bruce Cohen