E. R. Squibb Sons, Inc.

Steven Brandt

David M Floyd

John K Thottathil

Spencer David Kimball

Jerome L Moniot

Hypotensive activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is hydrogen or alkyl;

Amino substituted benzenepropanols

A method is provided for making substituted prolines of the structure ##STR1## wherein X is lower alkyl or aryl, R is H, lower alkyl or an alkali metal and Z is an N-protecting group, which method includes the step of reacting a compound of the structure ##STR2## wherein Z and R are as defined above and Q is Br. tosyloxy or mesylate, with an organic copper lithium compound of the structure

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Plainsboro, NJ, United States of America

Steven Brandt