The University of New Mexico

The United States of America, as Represented by the Secretary, Department of Health and Human Services

US Government as Represented by the Secretary of the Army

Steven Bradfute

Larry A Sklar

Sina Bavari

Vojo P Deretic

Ravi Durvasula

Adinarayana Kunamneni

Gerardo Kaplan

Krishnamurthy Konduru

Eliseo F Castillo

Jerome Jacques

An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.

Filovirus antibodies and methods

The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits

This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.

Fusion protein comprising the extracellular domain of a filovirus glycoprotein fused to an immunoglobulin heavy chain constant region

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Albuquerque, NM, United States of America

Steven Bradfute