Pfizer Corporation

Amersham Health As

Amersham Plc

Steven Blair Coffey

Robert A Snow

Bruce A Lefker

Gregory L McIntire

Pal Rongved

Henry Raphael Wolfe

Paul Mark Henrichs

Kenneth Robert Hollister

Wolfgang Hans Heinrich Gunther

Anna Rydbeck

Marten Eriksen

Kevin K -c Liu

Oskar Axellson

Hakan Malmgren

Hou Chen

Tore Gjorsvik

6,7-Dihydro-5H-cyclopenta[b]pyridine and 5,6,7,8-tetrahydroquinoline compounds of Formula (I), including salts, hydrates and solvates thereof, that act as 5-HTreceptor ligands and their uses in the treatment of diseases linked to the activation of 5-HTreceptors are described herein. 

Cyclopentapyridine and tetrahydroquinoline derivatives

A medical or surgical device or tool that is designed to be implanted or inserted inside the human or mammalian body, having at least part of its surface coated whereby the ultrasound visibility of said device or tool in vivo is enhanced, wherein the coating comprises one or more of the following: (i) a matrix material containing a plurality of contrast enhancing elements; (ii) magnesium; (iii) a liquid or polymer which alters its ultrasound imaging properties upon elevating the temperature from ambient to physiological temperature; (iv) a liquid or polymer which alters its ultrasound imaging properties as a result of a change in pH; (v) an essentially non-polymeric bio-compatible compound which forms a discontinuous coating. Preferably the device or tool is a radioactive source for use in brachytherapy, and in particular a radioactive seed.

Medical tools and devices with improved ultrasound visibility

The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

Methods of photoacoustic imaging

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Pawcatuck, CT, United States of America

Steven Blair Coffey