Pacific Biosciences of California, Inc.

Steven Benjamin Warren

Stephen Wilson Turner

Jonas Korlach

Annette Claire Grot

A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.

Systems and methods for selectively addressing sparsely arranged electronic measurement devices

Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential. The output of the active pixel represents a comparison or difference between successive frames. The differential can represent the state of the sensor element in the pixel at the end of one frame compared to the state of the sensor element of the frame, at the end of the prior frame.

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New York, NY, United States of America

Steven Benjamin Warren