Wake Forest University

Other

Hoffmann-la Roche Inc.

The Penn State Research Foundation

Steven B Mizel

Ulrich Andreas Gubler

Peter T Lomedico

Daniel J Wozniak

Eric T Weimer

Anna Nichole Honko

The invention provides compositions and fusion proteins comprising a flagellin adjuvant and aantigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against(e.g., to prevent and/or treatinfection).

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The invention provides a fusion protein comprising a flagellin adjuvant and aantigen. Also provided are compositions comprising a flagellin adjuvant and aantigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and aantigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against

The invention relates to the cloning of the human interleukin-1&agr; gene, its engineering into suitable expression vectors, hosts transformed with such expression vectors, and production of biologically active recombinant human interleukin-1&agr;.

Recombinant human recombinant human interleukin-1&agr;

The invention relates to the cloning of the human IL-1 gene, its engineering into suitable expression vectors, transformation of host organisms with such expression vectors and production of biologically active recombinant human IL-1 by culture of such transformed cells. Additionally, the invention relates to the isolation and use of the resulting recombinant human IL-1 polypeptides.

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Lewisville, NC, United States of America

Steven B Mizel