University of Missouri

Mo-sci Corporation

Ets Technology Holdings LLC

Other

Prosidyan, Inc.

Ets Technology Holding LLC

Steven B Jung

Delbert E Day

Charanpreet S Bagga

Thomas E Day

Roger F Brown

Hyun W Bae

A more robust packaging structure for maintaining the integrity of compressible biologically active materials during storage and especially during transportation is provided. These containers protect the materials from shock, vibration, deformation, or separation from agitation. The compressible materials may be in the form of synthetic fibers, and may include a composite of fibers and beads or granules. Suitable materials that may benefit from such a robust packaging structure include synthetic materials that comprise a biologically active ceramic or glass.

Protective packaging structure for compressible materials

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Wound care device having dynamic bioactive nanofiber scaffolding

Dynamic bioactive nanofiber scaffolding

A glass, glass ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded be an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels and nerves.

Bioactive glass scaffolds, and method of making

Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (BO) intermixed into a carrier which is an ointment, cream, or surgical glue.

Wound care compositions

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.

Bone graft implants containing allograft

A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

A biocompatible composition for tissue repair or regeneration in mammals comprising one or more glass former compounds selected from the group consisting of BO, PO, and SiOand director elements selected from the group consisting of Cu, Sr, Zn, Fe, Mn, Cr, V, Nb, Mo, W, Ba, Co, S, Al, Ti, Y, Mg, Si and/or Ni to promote in vivo calcium compound formation of calcium carbonate or other calcium compounds other than hydroxyapatite. Upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids.

Controlling calcium compound formation in biocompatible materials for tissue regeneration and repair in mammals

A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % BO, and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.

Growing community of inventors

Rolla, MO, United States of America

Steven B Jung