Innercool Therapies, Inc.

Acutus Medical, Inc.

Innercool Therapias, Inc.

Steven Anthony Yon

John Daniel Dobak, Iii

Michael Magers

Hans W Kramer

Randell Louis Werneth

Juan C Lasheras

Daniel Welsh

Derrick Ren-yu Chou

Rebecca S Inderbitzen

Ahmad Falahatpisheh

Leo Mariappan

Christoph Scharf

Alexander J Asconeguy

Marcus Frederick Julian

Michael Oliveira

J Christopher Flaherty

R Maxwell Flaherty

Graydon Ernest Beatty

Ricardo David Roman

James Calvin Allan

Dennis M O'Brien

Gerald M Stobbs, Iii

Tom Esbeck

Rob Andre Pescar

Alexander Higgins

Devon Sowell

Mark Van Nest

Kevin P Gilmartin

Brandon Pratt Noheaikaika Lee

Timothy J Corvi

John D Dobak

Min Zhu

Stephen R Cooper

Xinwei Shi

Jun Song

Wesley D Jones

Ragnar Olafsson

Hongping Dai

Nathan Angel

Haizhe Zhang

Weiyi Tang

Derrick Ren-Yu Chou

Provided herein are systems and methods for performing localization within a patient. A method of localization within a body comprises providing at least one processor coupled to at least one data storage device, establishing and calibrating a localization coordinate system within a body by executing a first localization mode by the at least one processor, recalibrating the localization coordinate system by executing a second localization mode by the at least one processor, and localizing a device within the localization coordinate system using the first localization mode and the second localization mode, by the at least one processor. The first localization mode can be an impedance-based localization mode and the second localization mode can be magnetic-based localization mode, or vice versa.

Systems and methods for performing localization within a body

An ablation system comprises: an ablation catheter and a console. The ablation catheter comprises: a shaft including a proximal end, a distal portion and a distal end; an ablation element configured to deliver energy to tissue; and a force maintenance assembly comprising a force maintenance element and configured to control and/or assess contact force between the ablation element and cardiac tissue. The console is configured to operably attach to the ablation catheter and comprises: an energy delivery assembly configured to provide energy to the ablation element. Methods of ablating tissue are also provided.

Ablation system with force control

A cardiac information dynamic display system comprises: one or more electrodes configured to record sets of electric potential data representing cardiac activity at a plurality of time intervals; and a cardiac information console, comprising: a signal processor configured to: calculate sets of cardiac activity data at the plurality of time intervals using the recorded sets of electric potential data, wherein the cardiac activity data is associated with surface locations of one or more cardiac chambers; and a user interface module configured to display a series of images, each image comprising: a graphical representation of the cardiac activity. Methods of providing cardiac activity data are also provided.

Cardiac mapping system with efficiency algorithm

An intravascular heat transfer device is provided with a mixing-inducing surface formed by an easily manufacturable process. The device can have a plurality of elongated, articulated segments, each having a mixing-inducing exterior surface. A flexible joint connects adjacent elongated, articulated segments. The device may be conveniently formed, e.g., by vapor deposition or molding, and further lacks undercuts so that the same may be conveniently removed from, e.g., a two-part mold.

Method of manufacturing a heat transfer element for in vivo cooling without undercuts

The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.

Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation

Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation

An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.

Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection

A device and method for providing body cooling for treating fever. The cooling device applies cooling to blood flowing in a vein or artery, e.g., the vena cavae, that is then distributed throughout the body.

Fever regulation method and apparatus

A method and apparatus is provided for determining an effective thermal mass of a patient. The effective thermal mass is employed to determine a gain factor used in a feedback control system controlling patient temperature. The method begins by inducing hypothermia or hyperthermia in at least a selected portion of the patient with a device having a heat transfer surface. Next, power is transferred between the device and the patient. A change in temperature over time, which arises in the selected portion of the patient, is measured while performing the step of inducing hypothermia or hyperthermia. Finally, an effective thermal mass is calculated based on the measured power and the measured temperature change over time.

Method for determining the effective thermal mass of a body or organ using a cooling catheter

Method of manufacturing a heat transfer element for in vivo cooling

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San Diego, CA, United States of America

Steven Anthony Yon