Afferent Pharmaceuticals, Inc.

Intuit, Inc.

Triact Therapeutics, Inc.

Steven A Smith

Anthony P Ford

Prabha N Ibrahim

Michael Amore Scalora

Thomas F White

Harold R Davidson

Kathleen Sereda Glaub

Michael M Kitt

Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Rand Rare as defined herein.

Diaminopyrimidine P2X3 and P2X2/3 receptor modulators for use in the treatment of cough

Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Crystalline salts and polymorphs of a P2X3 antagonist

The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor metabolite. Catecholic butane metabolites can serve as dual kinase inhibitors for purposes of methods described herein.

Cancer therapy

Support is provided for multiple late binding objects with a same identifier, in an operating environment that only supports registration of a single late binding object with the same identifier. Each of a plurality of processes is associated with one of a plurality of late binding objects, such that at least two processes are each associated with a separate late binding object having the same identifier. Responsive to one of the plurality of processes attempting to access a late binding object by its identifier, a determination is made as to which late binding object is associated with the process. The associated late binding object is made available to the process.

Growing community of inventors

San Mateo, CA, United States of America

Steven A Smith