Abbott Laboratories Corporation

Other

Abbvie Inc.

Steven A King

Steven J Wittenberger

Daniel J Plata

Charles W Hutchins

Andrew Stewart Tasker

Gang Liu

Steven Armen Boyd

Martin Winn

Bryan K Sorensen

Thomas W Von Geldern

Hwan-soo Jae

Bruce G Szczepankiewicz

Kenneth J Henry

Jeffrey A Kester

Howard E Morton

Jien-Heh J Tien

Sou-Jen Chang

Eric J Stoner

Ramiya H Premchandran

Lawrence Kolaczkowski

Michael S Allen

Stephen L Condon

Subhash R Patel

Hemant H Patel

John A DeMattei

Sukumar Manna

Paul J Nichols

Yi-Yin Ku

Paul Nichols

Elaine C Lee

Anne E Bailey

Frederick A Plagge

Tim Grieme

Louis Seif

John J Demattei

Steven C Blum

Anthony Ralph Haight

James J Napier

Russell Drew Cink

David R Hill

David A Riley

Yu-Ming M Pu

Padam N Sharma

Marvin Robert Leanna

Michael Rasmussen

Arthur J Cooper

Margaret Chi-Ping Hsu

Francis A Kerdesky

Gregory S Wayne

Lakshmi Bhagavatula

Maureen Ann McLaughlin

John E Lallaman

Ashok K Gupta

Prasad S Raje

Robert J Padley

Matthew John Peterson

Mahendra N Deshpande

Todd J Janus

Jonathan P Pease

Francis A J Kerdesky

Steven Harrelson

Matthew J Peterson

Marvin R Leanna

Maureen A Mclaughlin

Paul Hewitt

Tom Keller

William Forbes

Enoch Bortey

Pravin Chaturvedi

David Riley

Hwan-Soo Jae

A tamper resistant cover assembly for a lock assembly operably connected to a shipping container is disclosed. The lock assembly has a closed configuration when a door of the shipping container is in a shut configuration. The tamper resistant cover assembly has a cover housing defining an interior chamber and a bottom opening in communication with the interior chamber. A slot is defined in the housing and being in communication with the interior chamber, the slot dimensioned to be configured to receive the lock assembly of the shipping container. A projection arm has a proximal end and distal end. The proximal end is connected to an inner surface of the cover housing wherein the projection arm extends into the interior chamber. The projection arm has an aperture therein. When the lock assembly of the shipping container is in the closed configuration, the cover assembly is positioned on the shipping container wherein the slot is configured to receive the lock assembly. The projection arm is positioned proximate the lock assembly wherein the aperture is generally aligned with openings in the lock assembly. The bottom opening is configured to receive a padlock wherein a shackle of the padlock is configured to be inserted through the projection arm aperture, the shackle configured to be inserted into the openings of the lock assembly wherein the padlock is configured to be locked to place the lock assembly in a locked configuration, wherein the cover assembly is configured to provide a tamper-resistant configuration for the lock assembly.

Cover assembly for lock assembly of a shipping container

A continuously variable transmission system comprising an input and output rotational member each with a first circular end and a second circular end is disclosed. The output rotational member is located such that the second circular input member end faces the first output member end and the input and output rotational members share a tangential plane. A first and second idler wheel, attached to an idler shaft, contact the input and output rotational members. The first and second idler wheels and idler shaft are configured to translate rotation from the input rotational member to the output rotational member.

Cone and idler continuously variable transmission

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

Preparation of quinoline-substituted carbonate and carbamate derivatives

A compound of the formula (I):or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.

Process for the preparation of cell proliferation inhibitors

The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.

Process for the preparation of chiral glucocorticoid receptor agents

Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

Process for the preparation of 6-O-propargyl erythromycin derivatives

In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2&prime;-substituted and optionally 4&Prime;-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Process for preparing 6-o-substituted erythromycin derivatives

Treatment of diseases using endothelin antagonists

The invention relates to a process of preparing a chiral compound of the formula:

Enantioselective synthesis of 3-aminopyrrolidines

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Gurnee, IL, United States of America

Steven A King