Lakewood Amedex, Inc.

Ischemix, LLC

Arch Biosurgery, Inc.

Other

Surface Logix, Inc.

Steven A Kates

Reinier Beeuwkes

Alexander Baguisi

Steven Parkinson

Ralph Casale

Alan S Lader

Randolph B Sleet

Rutledge Ellis-Behnke

Terrence Norchi

Keith Johnson

David A DeWahl, Jr

Michael J Grogan

David C Duffy

Olivier Schueller

Emanuele Ostuni

Paul Sweetnam

Stewart Campbell

Patrick C O'Connor

Alexander B Baguisi

Keith Arthur Johnson

Rutledge G Ellis-Behnke

David Dewahl

Gel formulations having antimicrobial activity are disclosed. Methods of using the gel formulation are further disclosed.

Bisphosphocin gel formulations and uses thereof

Antimicrobial compounds and compositions of Formulas (V), (VI), (VII), (VIII), and (IX), and methods of use are disclosed.

Antimicrobial compounds, compositions, and uses thereof

A method of treating an infection of a lung in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.

A method of treating an infection of at least one of a wound or a ulcer in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.

The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.

Compositions and methods for treating traumatic brain injury

Methods and pharmaceutical compositions including Bisphosphocins for treating oral mucositis in a patient are disclosed.

Methods and compositions for treating oral mucositis

Gel formulations including a Bisphosphocin having antimicrobial activity are disclosed. Methods of using the gel formulations including a Bisphosphocin are further disclosed.

Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.

Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.

Growing community of inventors

Needham, MA, United States of America

Steven A Kates