Northfield Laboratories, Inc.

Norhtfield Laboratories, Inc.

Steven A Gould

Gerald Moss

Arthur L Rosen

Lakshman R Sehgal

Richard E De Woskin

Hansa Sehgal

Marc Doubleday

Richard E DeWoskin

George Hides

Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.

Method for treating patients with massive blood loss

An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.

Acellular red blood cell substitute

A process is disclosed for the preparation of an essentially tetramer-free, essentially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin which comprises separating red blood cell stroma from blood by means of heat treating step to remove stromal contaminants and filtration or centrifugation or both, pyridoxylating, polymerizing, and removing essentially all of the remaining unmodified tetramer.

An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its uses and a process for preparing said acellular red blood cell substitute.

Growing community of inventors

Lake County, IL, United States of America

Steven A Gould