Abbott Laboratories Corporation

Bracco Imaging S.p.a.

Steven A Chamberlin

Ashok V Bhatia

Xiu Chun Wang

Keith A Drengler

John J Hufnagel

Richard A Lorenzini

David A Riley

Arthur J Cooper

Denton C Langridge

Jufang Barkalow

Azad Hossain

Deborah A Davis

Luping Liu

Gregg E Robinson

The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

Process for the preparation of iopamidol

This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

Method for the preparation of fluticasone and related 17&#x3b2;-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

A compound and salts and enantiomers thereof, having the formula:wherein R7 is an acyl group.

A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

Processes for the preparation of D-chiro-inositol

Provided is a novel process for the preparation of iohexol having reduced number of isolated intermediates and significantly reduces or eliminates the use of ion-exchange resins required to desalinate the final product.

Process for the preparation of iohexol

The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Selective alkylation of an alcohol substituted phenol compound

A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.

Process for the preparation and isolation of atracurium besylate

A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:

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Waukegan, IL, United States of America

Steven A Chamberlin