Biotek Solutions, Incorporated

Other

Ventana Medical Systems, Inc.

Biotek Instruments, Inc

Steven A Bernstein

Page A Erickson

Stephen Barker

A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among the plurality of processing stations, and a processor, which may select the order, timing and location of the tissue sample. The robotic device may comprise a bench robot with rectilinear motion or a rotatable tower. The processing stations may be disposed in a set of grid locations, which comprise workstations for performing individual steps of the procedures. In response to timing information about the procedures, the processor may select the sample to be moved. The processor may examine the multiple procedures for timing conflicts and it may adjust the sequence of steps for the procedures, the timing of steps with a specified range of times, or the order of the samples in order to avoid conflicts and to minimize the total time required by the system to complete the procedures. The operator may create or edit templates for workstations, create or edit lists of process steps for procedures, monitor the progress of ongoing procedures, or override the determination of what process steps to perform.

Automated tissue assay using standardized chemicals and packages

A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among a plurality of processing stations, and a processor, which may select the next tissue sample to move, when to move it, and where to move it to. The processor may direct the robotic arm to interleave the differing process steps. The processor may select a tissue sample to be moved in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may comprise a graphic interface by which an operator may specify the steps of a procedure. A display of grid locations may comprise symbols for the workstations, which an operator may identify with a pointing device such as a mouse. The operator may create a list of process steps for a procedure by selecting a sequence of workstations with the mouse, and associating timing or other information for each process step with the selected workstation. The operator may also choose to select a list of stored process steps for a procedure.

Method and apparatus for automated tissue assay

A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which moves the different tissue samples among a plurality of processing stations, and a processor, which selects the next tissue sample to move, when to move it, and where to move it to. The processor directs the robotic arm to interleave the differing process steps. The processing stations comprise workstations for performing individual steps of the tissue assay procedures, such as solution trays. The processor selects a tissue sample to be moved in response to timing information about the procedures. While the processor is directing the robotic arm to move, the processor monitors progress information and can alter the sequence of process steps in response to the progress information and information from an operator.

Automated tissue assay using standarized chemicals and packages

. A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among the plurality of processing stations, and a processor, which may select the order, timing and location of the tissue sample. The robotic device may comprise a bench robot with rectilinear motion or a rotatable tower. The processing stations may be disposed in a set of grid locations, which comprise workstations for performing individual steps of the procedures. In response to timing information about the procedures, the processor may select the sample to be moved. The processor may examine the multiple procedures for timing conflicts and it may adjust the sequence of steps for the procedures, the timing of steps with a specified range of times, or the order of the samples in order to avoid conflicts and to minimize the total time required by the system to complete the procedures. The operator may create or edit templates for workstations, create or edit lists of process steps for procedures, monitor the progress of ongoing procedures, or override the determination of what process steps to perform.

A system for performing a plurality of independent analysis procedures simultaneously, each procedure having a sample and at least one process step for operating on that sample the system having a robotic device for moving a sample among a plurality of processing stations where the robotic device comprises substrate to which are coupled a plurality of tiles each one of the tiles disposed at a selected location on the substrate; a plurality of reagent trays coupled to the tiles, each one of the reagent trays having substantially identical shape and size; a robotic arm disposed for reaching substantially all the tiles; and capable of coupling and decoupling from a sample holder, the sample holder capable of holding at least one sample in a selected position, whereby the robotic arm is capable of moving the sample from a first one of the reagent trays to a second one of the reagent trays; and a processor for selecting, at a plurality of times a sample to be moved, and for directing the robotic arm to move the sample to be moved; the processor capable of directing the robotic arm to interleave the process steps of the plurality of independent analysis procedures in a sequence conforming to a predetermined range of durations for each one of the process steps.

System for performing a plurality of independent tissue analysis

A system for performing a plurality of independent analysis procedures simultaneously, each the procedure having a sample and at least one process step for operating on that sample the system having a robotic device for moving sample among a plurality of processing stations where the robotic device comprises substrate to which are coupled a plurality of tiles each one of the tiles disposed art a selected location on the substrate; a plurality of reagent trays coupled to the tiles each one of the reagent trays having substantially identical shape and size; a robotic arm disposed for reaching substantially all the tiles; and comprising means for coupling and decoupling from a sample holder, the sample holder having a means for holding at least one sample in a selected position, whereby the robotic arm is capable of moving the sample from a first one of the reagent trays to a second one of the reagent trays; and a processor for selecting, at a plurality of times a sample to be moved, and for directing the robotic arm to move the sample to be moved; the processor having means for directing the robotic arm to interleave the process steps of the plurality of independent analysis procedures in a sequence conforming to a predetermined range of durations for each one of the process steps.

A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic device, which may cause the different tissue samples to be processed by processing stations, and a processor, which may select the next process step. The processor may direct the robotic device to interleave the differing process steps. The processor may select a next process step in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may also optimize the order in which process steps are performed to minimize the total time required by the system to complete the procedures, for example by generating a plurality of possible sequences, evaluating each sequence for total expected time, and selecting the best sequence available.

A system which performs a plurality of independent analysis procedures simultaneously, comprising a robotic arm and a processor, which may direct the robotic arm to interleave the differing process steps. The processor may select a tissue sample to be moved in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may also optimize the order in which samples are moved to minimize the total time required by the system to complete the procedures, e.g., by generating a plurality of possible sequences, evaluating each sequence for total expected time, and selecting the best sequence available. The processor may comprise a graphic interface by which an operator may specify the steps of a procedure.

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Los Olivos, CA, United States of America

Steven A Bernstein