Hoffmann-La Roche Inc.

The United States of America

Steve Yik-Kai Tam

Ming-Chu Hsu

Manfred Weigele

John Joseph Partridge

Robert Alan Goodnow, Jr

Donna Mary Huryn

Percy Sarwood Manchand

Hiroaki Mitsuya

James Valentine Earley

Tai-Nang Huang

Anne R Bellemin

Samuel Broger

Peter S Belica

Antisense oligomers of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are independently hydrogen, lower alkyl or acyl;

Antisense oligomers

A method for treating viral infections in a patient with aryl-(2-pyrryl) ketone compound and compositions.

Method for treating retroviral infections with aryl-(2-pyrryl) keytone

Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.

Substituted amino-benzodiazepines having anitviral activity

Isomeric derivatives of 2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine wherein the adenine or guanine base is attached to the 1' position of the iso-dideoxysugar residue by the 9-N position, the novel intermediates used in the synthesis of these compounds, and a method for treating a subject infected with a retrovirus by administering the compounds of the invention.

Isomeric dideoxynuclesides

Method for treating retroviral infections with aryl-(2-pyrryl) ketone

A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine.

Intermediate compounds and an improved procedure for the synthesis of

A-B-C wherein A and C are each independently 2',3' dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.

Growing community of inventors

West Caldwell, NJ, United States of America

Steve Yik-Kai Tam