Element Biosciences, Inc.

Alcon, Inc.

Steve Xiangling Chen

Michael Previte

Chunhong Zhou

Minghao Guo

Derek Fuller

Molly Min He

Matthew William Kellinger

Sinan Arslan

Junhua Zhao

Lorenzo Berti

Hui Zhen Mah

Brent G Duchon

Richard J Michaels

Muhammad Al-Qaisi

Muhammad K Al-Qaisi

Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Multivalent binding composition for nucleic acid analysis

Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications.

High performance fluorescence imaging module for genomic testing assay

Systems and methods are disclosed for performing ophthalmic optical coherence tomography with multiple resolutions. In some embodiments, a system comprises a light source, an output lens, and a set of optical components between the light source and the output lens, the set of optical components comprising an afocal zoom telescope. The set of optical components is adapted to provide imaging both at a first field of view with a first resolution and at a second field of view with a second resolution, wherein the first field of view is wider than the second field of view and the second resolution is higher than the first resolution. A method of performing ophthalmic optical coherence tomography with multiple resolutions may be performed using one or more of the systems described herein.

Ophthalmic optical coherence tomography with multiple resolutions

Imaging systems and methods comprising imaging a first interior surface and a second interior surface of a flow cell are described. In some embodiments, the imaging systems may comprise: a) an objective lens; b) at least one image sensor; and c) at least one tube lens disposed in an optical path between the objective lens and the at least one image sensor; wherein the at least one tube lens is configured to correct imaging performance such that images of the first interior surface of the flow cell and the second interior surface of the flow cell have substantially the same optical resolution.

Tube lens design for improved depth-of-field

Methods and systems for sequencing a nucleic acid molecule are described that comprise imaging a first surface and an axially-displaced second surface using a compensation-free optical system, the system comprising an objective lens and at least one image sensor, wherein said optical system has a numerical aperture (NA) of less than 0.6 and a field-of-view (FOV) of greater than 1.0 mm; and) processing the images of the first surface and the axially-displaced second surface to correct for optical aberration such that the images of the first surface and the axially-displaced second surface have substantially the same optical resolution.

Nucleic acid sequencing systems

Growing community of inventors

San Diego, CA, United States of America

Steve Xiangling Chen