Third Millennium Engineering LLC

Biodynamics LLC

Fastenletix, L.l.c.

Steve Tatar

James D Ralph

Joseph P Errico

Thomas J Errico

Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend on the composition of individual modules comprising the device. The modules may be cylinders, disks, tiles or tubes comprised of a bioabsorbable polymer and a therapeutic agent. The therapeutic agent(s) may be homogeneously distributed throughout the polymeric body of the device or contained within a cavity within a module comprising the device, or both. The device(s) may be threaded or attached to a prosthesis by a biodegradable adhesive. The modular devices may also be formed into tapered plugs for insertion into a mating receptacle. In another embodiment, the drug delivery device may be inserted within a mesh bag that may be attached to a soft tissue as, for example, by sutures, for localized controlled dispensation of a therapeutic agent.

Bioabsorbable plugs containing drugs

A modular polyaxial pedicle screw and orthopaedic rod implant device including same includes a shaft portion, a cuff, a stem portion, and a rod coupling sub-assembly. The shaft portion is designed to be inserted into the pedicle, has a recess formed in its top, and includes a threading formed on the exterior surface around the recess. The stem portion is a threaded post having an enlarged ball formed at the base thereof, the ball being ideally suited to polyaxially rotate within the recess of the shaft. The cuff is a cylindrical element designed to seat around the interface of the ball portion of the stem and the recess of the shaft, initially so that the stem and shaft may polyaxially rotate relative to one another, and subsequently to hold the stem and shaft in final securement. The rod coupling sub-assembly consists of a rod coupling element which is mountable on the post portion of the stem, and a top locking nut which secures the rod coupling element to the post between the nut and the cuff. Spacer elements may be utilized which are positioned on the post between the cuff and the rod coupling element to permit axial variability on the stem in addition to the angular variability inherent in the shaft and stem interface.

Modular polyaxial locking pedicle screw

A compression locking variable length cross-link device having modular components, including rod and/or pedicle screw coupling elements each having a hole which may be disposed co-linearly with respect to other such holes in opposing elements such that a threaded hinge-post may be inserted therein. A nut is utilized to compress the elements together to rigidly secure the elements once they have been properly positioned relative to one another. In an additional set of embodiments, a linkage member having an elongate hole therein may be used to couple similar elements thereto in a similar flexible hinge-post manner such that the elements may be coupled to the linkage member instead of to the opposing elements directly.

Multiple node variable length cross-link device

The present invention is a polyaxial locking screw plate assembly for immobilization of vertebral bones, via fixation to surfaces thereof. The invention includes a plate, having an upper portion and a lower portion, each of which has a pair of holes having a threaded upper portion and a tapered lower portion. Coupling elements, including slideably joined socket and cap portions, are mounted about the semi-spherical heads of bone screws, which are screwed through the holes in the plate and into the bone. The heads of the screws are polyaxially mounted in the socket portions and as such may be inserted into the bone at a variety of angles. The socket portions of the coupling elements have slots in them which permit crush locking of the heads of the screws once the sockets seat and are forceably driven into the tapered portions of the corresponding holes. The cap portions are threaded so they may be advanced into the upper portions of the corresponding holes, thereby further locking the coupling elements into the holes, and applying an additional driving force against the corresponding socket portions to crush lock the screw heads at the selected angle relative to the plate.

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Montville, NJ, United States of America

Steve Tatar