Hospira, Inc.

Abbott Laboratories Corporation

Other

Candescent Technologies Corporation

Steve T. Cho

Steve T Cho

Gene E Clark

Harlow B Christianson

John M Sperinde

Jennifer Y Sun

Christopher J Spindt

Theodore S Fahlen

Robert M Duboc

Kollengode S Narayanan

George B Hopple

Robert G Neimeyer

Alfred S Conte

Robert L Marion

John K O'Reilly

Vasil M Chakarov

David L Morris

David R Morris

The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.

Fluid flow measurement device

In a cosed-loop process, a controller uses a flow sensor to monitor the flow of a medicinal fluid being infused into a patient, to achieve a desired rate of flow. A relatively inexpensive peristaltic pump or electronically controlled valve can be used to vary the flow of the medicinal fluid through a fluid line. A Y site within the fluid line includes an integral flow sensor having an orifice. The flow sensor includes proximal and distal pressure sensors disposed on opposite sides of the orifice to monitor the distal and proximal pressure, producing a signal indicative of the rate of flow of the medicinal fluid through the fluid line. A signal produced by the controller is input to a motor driving the pump or to the valve to vary the rate of flow as required to achieve the desired infusion rate of the medicinal fluid.

Closed-loop IV fluid flow control

The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a beveled non-coring tip. Preferably arrays of such microneedles are fabricated utilizing conventional semiconductor derived micro-scale fabrication techniques. A dot pattern mask is formed on an upper surface of a silicon substrate, with each orifice of the dot pattern mask corresponding to a desired location of a microneedle. Orifices are formed that pass completely through the substrate by etching. A nitride pattern mask is formed to mask all areas in which a nitride layer is not desired. A nitride layer is then deposited on the bottom of the silicon substrate, on the walls of the orifice, and on the top of the silicon substrate around the periphery of the orifice. The nitride layer around the periphery of the orifice is offset somewhat, such that one side of the orifice has a larger nitride layer. Anisotropic etching is used to remove a substantial portion of the substrate, creating a plurality of angular, blunt, and generally pyramidal-shaped microneedles. A subsequent removal of the nitride layer, followed by an isotropic etching step, softens and rounds out the blunt angular microneedles, providing generally conical-shaped microneedles. The uneven nitride layer adjacent the orifice ensures that the microneedles will include a beveled tip. Such microneedle arrays are preferably incorporated into handheld diagnostic and drug delivery systems.

Microneedles for minimally invasive drug delivery

In a closed-loop process, a controller uses a flow sensor to monitor the flow of a medicinal fluid being infused into a patient, to achieve a desired rate of flow. A relatively inexpensive peristaltic pump or electronically controlled valve can be used to vary the flow of the medicinal fluid through a fluid line. A Y site within the fluid line includes an integral flow sensor having an orifice. The flow sensor includes proximal and distal pressure sensors disposed on opposite sides of the orifice to monitor the distal and proximal pressure, producing a signal indicative of the rate of flow of the medicinal fluid through the fluid line. A signal produced by the controller is input to a motor driving the pump or to the valve to vary the rate of flow as required to achieve the desired infusion rate of the medicinal fluid.

Methods and structures are provided which support spacer walls in a position which facilitates installation of the spacer walls between a faceplate structure and a backplate structure of a flat panel display. In one embodiment, spacer feet are formed at opposing ends of the spacer wall. These spacer feet can be formed of materials such as ceramic, glass and/or glass frit. The spacer feet support the corresponding spacer wall on the faceplate (or backplate) structure. Tacking electrodes can be provided on the faceplate (or backplate) structure to assert an electrostatic force on the spacer feet, thereby holding the spacer feet in place during installation of the spacer wall. The spacer wall can be mechanically and/or thermally expanded prior to attaching both ends of the spacer wall to the faceplate (or backplate) structure. The spacer wall is then allowed to contract, thereby introducing tension into the spacer wall which tends to straighten any inherent waviness in the spacer wall. Alternatively, spacer clips can be clamped onto opposing ends of a spacer wall to support the spacer wall during installation. The spacer clips can provide electrical connections to face electrodes located on the spacer wall.

Self-standing spacer wall structures and methods of fabricating and installing same

A micro-machined absolute pressure sensor and process for making the same. A semiconductor membrane having a welled portion connected to a planar periphery is formed in recess in a silicon substrate through etching and boron diffusion. A dielectric pad is formed on a portion of the planar periphery, and a bonding layer of polysilicon or amorphous silicon is deposited over the semiconductor membrane and the dielectric pad. After an etching process that defines the outline of the semiconductor membrane, the bonding layer is bonded to a nonconductive substrate in a vacuum using electrostatic bonding or wafer bonding, forming a vacuum-sealed reference cavity. A first and a second conductor are disposed on an upper surface of the nonconductive substrate. The first conductor serves as a capacitor plate disposed within the reference cavity and is connected to a transfer lead that passes from the cavity. The transfer lead is electrically isolated from the semiconductor membrane by the dielectric pad. The second conductor is electrically connected to the semiconductor membrane. The semiconductor membrane and the capacitor plate store an electrical charge that varies as a function of the distance between the capacitor plate and the semiconductor membrane. The semiconductor membrane flexes in response to pressure, changing the capacitance and the charge, so as to indicate the pressure of external fluid acting on the semiconductor membrane.

Micro-machined absolute pressure sensor

A monolithic flow controller for controlling the rate at which a medicinal liquid is administered to a patient. The monolithic flow controller includes one or more virtual valves that, because of their relatively small opening size (less than 0.5 &mgr;m in diameter), only permit fluid to flow through the valve when a forward bias voltage is applied. If a reverse bias voltage or no voltage is applied, fluid flow through the opening is inhibited. The fluid rate through the device is monitored using two pressure sensors or a differential pressure sensor that determine the differential pressure along the flow path through the device or relative to the external ambient pressure. The flow through the device is equal to the product of the differential pressure and the conductance of the channel in the flow controller. A capacitive bubble sensor is optionally provided to detect bubbles in the medicinal liquid being administered to the patient. The flow controller can be made sufficiently small to be injected into a patient's cardiovascular system or other portion of the patient's body through a hypodermic syringe and needle, or it can be implanted in the patient's body at a desired site. The medicinal liquid can be contained within an integral pressurized fluid reservoir, administered by gravity feed, or conveyed by a pump to an inlet port of the flow controller.

Monolithic high performance miniature flow control unit

A spacer (,or,A/,B) situated between a faceplate structure (,) and a backplate structure (,) of a flat panel display is configured to be self standing. In one implementation, a pair of spacer feet (,or,and,or,) are located over the same face surface, or over opposite face surfaces, of a spacer wall (,) near opposite ends of the wall. An edge electrode (,or,) is located over an edge surface of the spacer adjacent to the faceplate structure or the backplate structure. In another implementation, a spacer clip (,A or,B) clamps opposite face surfaces of a spacer wall (,) largely at one end of the wall.

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Sunnyvale, CA, United States of America

Steve T Cho