Katholieke Universiteit Leuven, Ku Leuven R&d

Vib Vzw

Steve Swinnen

Johan Thevelein

Maria Remedios Foulquie-Moreno

Annelies Goovaerts

Thiago Martins Pais

Françoise Dumortier

Maria Remedios Foulquie Moreno

Maria Remedios FoulquiÉ Moreno

The disclosure relates to a specific yeast allele of KIN3 that is involved in maximal alcohol accumulation and/or in tolerance to high alcohol levels. Preferably, the alcohol is ethanol. In a preferred embodiment, this specific allele is combined with specific alleles of ADE1 and/or VPS70. More specifically, the disclosure relates to the use of these alleles for the construction and/or selection of high alcohol tolerant yeasts, by stacking of positive alleles, or the selection and construction of low alcohol producing yeasts by stacking of negative alleles.

Yeast alleles involved in maximal alcohol accumulation capacity and tolerance to high alcohol levels

The present disclosure relates to the identification of a QTL associated with high ethanol tolerance inspp. More specifically, it relates to specific alleles of MKT1 and APJ1 possibly combined with a specific allele of SWS2 that are important in obtaining a high ethanol tolerance inspp. It relates further to the use of such alleles in the construction of high ethanol tolerant strains, and the use of these alleles in screening for ethanol tolerance.

Specific alleles important for ethanol tolerance

Growing community of inventors

Zichem, Belgium

Steve Swinnen