University of Central Florida Research Foundation Inc

University of Oklahoma

Steve Sezate

Sudipta Seal

Swanand D Patil

James F McGinnis

Lily L Wong

Junping Chen

James F Mcginnis

Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

Inhibition of reactive oxygen species and protection of mammalian cells

Growing community of inventors

Oklahoma City, OK, United States of America

Steve Sezate