Cima Labs Inc.

Steve Schuehle

Fred Wehling

Navayanarao Madamala

The disclosed invention includes a base coated acid formulation which is highly compressible. The disclosed invention also relates to formulations including both an effervescent couple and an acid sensitive active agent. Formulations having an acid neutralization capacity of under 5.0 are also described as are methods of making particulate base coated acid and dosage forms using same.

Base coated acid particles and effervescent formulation incorporating

A tableting aid including magnesium carbonate and an oil adsorbed thereon provides useful lubricating and disintegration properties. A free-flowing particulate flavoring additive including magnesium carbonate and a flavor oil adsorbed thereon, is also described.

Magnesium carbonate and oil tableting aid and flavoring additive

The present invention relates to oral effervescent dosage forms for the administrations of an intended ingredient to children, and processes for their administration.

Pediatric effervescent dosage form

A pharmaceutical dosage form incorporates microparticles which are susceptible to rupture upon chewing or which are adapted to provide substantially immediate release of the pharmaceutical ingredient contained in the microparticles. These microparticles are provided in a tablet with an effervescent disintegration agent. When the tablet is taken orally, the effervescent disintegration agent aids in rapid dissolution of the tablet and hence permits release of the microparticles, and swallowing of the microparticles, before the pharmaceutical ingredient is released from the microparticles. The system therefore provides particularly effective taste masking.

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Minneapolis, MN, United States of America

Steve Schuehle