Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Steve Ritland

Urvashi Hooda Dhingra

Kapil Dhingra

Lars Holger Breimer

Disclosed is a method of treating a patient suffering from cancer. The method comprises administering to a patient over a period of up to about 15 days a first component and a second component. The first component consists of a pharmaceutical composition containing as an active ingredient a compound of formula I or a pharmaceutically acceptable salt or ester of said compound. The second component consists of an injection solution containing as an active ingredient paclitaxel. The amount of each component in the combination is such that the combination is therapeutically effective. The components are administered concomitantly or sequentially in a three week to four week treatment cycle for as long as the tumor remains under control and the patient tolerates the regimen.

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Paterson, NJ, United States of America

Steve Ritland