Rarecyte, Inc.

Steve Quarre

Ronald C Seubert

Joshua Nordberg

David Edward Stewart

Daniel E Campton

Lance U'Ren

Jonathan Lundt

Edward Shafer

Jennifer Chow

Joel Smith

Paulina Varshavskaya

Ronald Seubert

David Stewart

Lance U'ren

Jonathan Erik Lundt

Daniel Campton

Disclosed are apparatus and methods for securely holding a substrate in a repeatable and predictable manner regardless of substrate inconsistencies or deformities. In particular, described are apparatus and methods for consistently, repeatedly, predictably and securely holding a microscope slide on or within an imaging device. The apparatus may include a holder having securing blocks for securely holding a microscope slide that can be adjusted to account for warpage or deformations that may occur in the microscope slide.

Holding a substrate within a secondary device

This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.

Automated substrate loading

This disclosure is directed to a device and a system for picking a target material from a sample.

Device, system, and method for selecting a target analyte

This disclosure is directed to an apparatus for securely holding a substrate, such as a microscope slide. A holder includes a frame including at least three walls, such as a base, a first arm, and a second arm. Each wall includes a platform or a portion of a platform to support the substrate. The first arm includes at least one securing block and a second arm opposite the first arm includes a secure bar with a securing block. The securing blocks include a ramp to guide the substrate off of the platforms and a stopper to set a maximum lift distance and to constrain the substrate.

Apparatus for holding a substrate within a secondary device

This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.

Apparatus, system, and method for collecting a target material

This disclosure is directed to a system and method for detecting a surface of a substrate within a scanner.

Detecting a substrate

This disclosure is directed to an apparatus, system and method for introducing a liquid into a vessel. A fluid layering system includes a pump connected to a line connected to a connector, such that the connector provides an air-tight fit with the vessel.

Apparatus, system, and method for introducing a liquid into a vessel

This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base, an anti-coagulant, and a nonsteroidal anti-inflammatory drug. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, or any combination thereof. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured.

Solution and method for adhering suspension components to a substrate

This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.

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Woodinville, WA, United States of America

Steve Quarre