University of Colorado

Steve Mark Helmke

Gregory Thomas Everson

Harry Drabkin

Becky De La Houssaye

Karl Pfenninger

Keith Mikule

A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Method for assessment of hepatic function and portal blood flow

A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Methods for monitoring treatment of chronic liver disease

Disease severity index for assessment of chronic liver disease

Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis

The present invention provides methods of identifying and using compounds that modulate cell motility. Such compounds can be used to inhibit cancer cell metastasis or promote neurite growth and regenaration. The methods generally relate to the repellent-receptor signalling pathway that controls cellular attachment and detachment to a substratum.

Method for identifying neurite-growth promoting agents

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Denver, CO, United States of America

Steve Mark Helmke