Boston Scientific Scimed, Inc.

Boston Scientific Corporation

Steve Kangas

Liliana Atanasoska

Yen-Lane Chen

James Q Feng

Gordon Kocur

Horng-Ban Lin

Michael Sean Owens

Maggie Zeng

Erik Joseph Haun

Eric Henderson

David K Johnson

Aaron Foss

Dave Ekberg

Jon Patterson

Michael Owens

Erik Haun

Edward Parsonage

Dave Sogard

Dominic Allocco

Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.

Nucleation of drug delivery balloons to provide improved crystal size and density

A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 &#x3bc;m or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

Medical device with crystalline drug coating

According to an aspect of the present invention, medical devices are provided which include a metallic substrate and a polymeric region disposed over and in contact with the metallic substrate. The polymeric region includes (a) a fluorine-containing polymer that contains at least one type of fluorine-containing monomer selected from a vinylidene fluoride monomer, a hexafluoropropylene monomer, and a combination thereof, and (b) an adhesion promoting copolymer that contains (i) at least one type of first monomer that covalently or non-covalently bonds with the metallic substrate and (ii) at least one type of second monomer selected from acrylate monomers, methacrylate monomers, fluorine-containing monomers, and combinations thereof.

Medical devices having fluorine-containing polymer coatings with improved adhesion

An ultraviolet curable lubricious coating including at least one lubricious polymer and at least one oxygen-insensitive crosslinkable polymer, methods of making and using the same, and articles coated therewith.

Lubricious coatings for medical device

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Woodbury, MN, United States of America

Steve Kangas