Chugai Seiyaku Kabushiki Kaisha

Steve Joel Brown

David Mark Wallace

Gary David Lopaschuk

Jason Roland Dyck

Jie Fei Cheng

Thomas Arrhenius

Sovouthy Tith

Charles Stanford Harmon

Mi Chen

Mark E Wilson

Masahiro Nishimoto

Lin Zhang

Alex Michael Nadzan

Yujin Huang

Rossy Serafimov

Masayuki Haramura

The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R, R, R, and Rare defined herein. 

Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases

The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds 

Method for preparing imidazole derivatives

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Steve Joel Brown