Philip Morris Products S.a.

Carefusion 207, Inc.

12th Man Technologies, Inc.

Other

Koninklijke Philips Corporation N.v.

Rain Bird Corporation

Ric Investments, Inc.

Carefusion 2200, Inc.

Vyaire Medical Consumables LLC

Vyaire Medical Capital LLC

Carefusion Corporation

Monitored Therapeutics, Inc

Viasys Manufacturing, Inc.

S & T Medical Technologies, Inc.

Elanco US Inc.

Steve Han

Alex Stenzler

Steven Ellis

Arthur Slutsky

Noe Zamel

Steven Duquette

James Tibbatts

Christopher Iain Davidson

Robin Craig Cocker

Ben Alexander King

Paul Mutti

William W Alston

Harold F Miller

Gardner Kimm

Terry Blansfield

Mabini Arcilla

Patrick Nguyen

Timothy Michael Evans

Thomas Westfall

Steve Duquette

Martin Stegenga

Christopher C Miller

Gilly Regev-Shoshani

Bildad Nyambura

Casey J Strange

Jane Granville Owens

Amy Louise Marr

David Matthew Young

Randall Lee Waln

Terry Shum

Mei-Sheng Teng

Jeffrey Kyle Hill

Khaja H Khan

Amy L Marr

Jane G Owens

Randall L Waln

Jeffrey K Hill

The present invention provides dry powder inhaler (DPI) devices () for dispensing dry powder and methods for using the same. The DPI devices feature vortex mechanisms for directing air in a turbulent manner sufficient to entrain an amount of a dry powder dose for delivery into a user's lungs. The DPI devices feature replaceable dry powder cartridges (). The DPI devices also feature a retractable configuration for storage and for accidental dispensing of dry powder. The DPI devices dispense dry powder in controlled dosages.

Dry powder inhaler

Dry powder inhalers are described. The dry powder inhaler includes an air inlet, a reservoir and an airway assembly. A mouthpiece airway is connected to a first airway of the airway assembly. An airway head is attached to the airway assembly and it extends into the reservoir cavity. In certain embodiments, the airway head has a sharpened or beveled edge. At least one airway assembly opening is present in the airway assembly for connecting the reservoir cavity to the first airway. Methods for dispensing dry powder into an airway of a dry powder inhaler and inhaling dry powder from a dry powder inhaler is also disclosed. Embodiments of a dry powder inhaler having a two-stage air movement are also described.

Dry powder inhaler device

A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.

System and method for controlling the harshness of nicotine-based dry powder formulations

A nasal interface is provided that can allow for delivery of flow of a gas to a patient for respiratory support while preventing injury or irritation to the patient. The nasal interface can include a nasal pillow set having a nasal pillow, which can engage against a nose, and relief port, which can permit a gas to be released from the nasal interface. A nasal cannula can include a cannula body to direct a gas through the nasal interface, and can have an opening to direct a gas out of the cannula body. The gas can be directed from the cannula body, through the opening, toward a nasal pillow and a patient's nare. The nasal interface can be coupled with a head harness, which can be worn on the patient's head, and can include a guide that extends toward the nasal interface.

Nasal cannula systems and methods

The present invention provides devices for holding one or more vapor sources in a media inhaler. The devices permit vapor from the one or more vapor sources to be introduced and entrained into a stream of inhaled media. The vapor insert device includes a hollow cylinder having a porous surface, an open anterior end, and an open posterior end. An anterior flange is attached to the open anterior end, and a posterior flange is attached to the open posterior end. The anterior flange and the posterior flange each have a diameter that is larger than a diameter of the hollow cylinder to form a circumferential space around the hollow cylinder.

Vapor insert for holding a vapor source

A nebulizer device includes an air intake port positioned downstream of a nebulizer element, and a mouthpiece positioned upstream of the nebulizer element. A flow sensor is coupled to a controller. The controller is configured to integrate an inhaled air flow signal received from the flow sensor for determining an inhaled air volume. The controller is also configured to turn on the nebulizer element when the inhaled air volume reaches a first predetermined threshold, and turn off the nebulizer element when the inhaled air volume reaches a second predetermined threshold. A method for targeted delivery of aerosolized particles to the lungs is also disclosed.

Device and method for targeted delivery of aerosolized particles to the lungs

A system for monitoring inspirable gas for delivery to a patient includes a branched breathing circuit having a first branch conduit and a second branch conduit. The first branch conduit is fluidly connected to a first gas source and the second branch conduit is fluidly connected to a second gas source, and the first and second branch conduits merge into a patient delivery conduit. The system includes a first flow sensor in the first branch conduit, a second flow sensor in the second branch conduit, and a third flow sensor in the patient delivery conduit. A control unit is electrically coupled to the first, second and third flow sensors. The control unit is configured to determine a blend of gas in the patient delivery circuit based on a measured flow from the third flow sensor and a measured flow from at least one of the first and second flow sensors.

Non-gas analyzer monitor of inspired gas concentration

A veterinary subject intranasal administration device includes a first support member portion including a septum interface portion sized for insertion into a nasal passage of the veterinary subject; an actuation mechanism connected to the first support member portion; and a fluid conduit having a distal end opposite a supported end, the distal end sized for insertion into the nasal passage of the veterinary subject, the fluid conduit being flexible and configured to receive fluid from a fluid source and discharge the fluid through the distal end into the nasal passage, the distal end of the fluid conduit being unsupported and movable relative to the septum interface portion.

Animal intranasal administration device, systems, and associated methods

A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.

Dry powder inhalers with partial dosage delivery

A method of reducing nicotine cravings is described. The method includes inhalation of a dry powder formulation containing a dose of nicotine by a subject seeking nicotine cravings reduction. The formulation includes amounts and concentrations of nicotine that are significantly lower than cigarettes or nicotine replacement therapies.

Nicotine formulations and methods of making and using the same

A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.

Dry powder inhaler and method of use

A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

Flavoring element for an inhalation device

Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.

Dual resistance dry powder inhaler

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Huntington Beach, CA, United States of America

Steve Han