Thermo Fisher Scientific (bremen) Gmbh

Thermo Finnigan LLC

Thermo Fisher Scientific Gmbh

Stevan Roy Horning

Alexander Alekseevich Makarov

Eduard V Denisov

Gerhard Jung

Wilko Balschun

Oliver Lange

Robert Malek

Alexander A Makarov

Silke Seedorf

Robert H Malek

John E P Syka

Reinhold Pesch

Andreas Wieghaus

Kai Jurgen Meyer

Alexander Makarov

Wilko c/o Thermo Electron Gmbh Balschun

John E Syka

A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.

IRMS sample introduction system and method

A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

Parallel mass analysis

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3d5;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3d5;, z) is the result of a perturbation W to an ideal field U(r, &#x3d5;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3d5;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2&#x3c0; radians over an ion detection period T.

Electrostatic trap

A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionized solvent and solvent ion vapors. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionized solvent vapors are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3d5;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3d5;, z) is the result of a perturbation W to an ideal field U(r, &#x3d5;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3d5;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3c6;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3c6;, z) is the result of a perturbation W to an ideal field U(r, &#x3c6;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3c6;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

Multiple ion injection in mass spectrometry

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3a6;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3a6;, z) is the result of a perturbation W to an ideal field U(r, &#x3a6;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3a6;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U' (r, &#x3a6;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3a6;, z) is the result of a perturbation W to an ideal field U(r, &#x3a6;, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3a6;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

Growing community of inventors

Delmenhorst, Germany

Stevan Roy Horning