Advanced Bioscience Laboratories, Inc.

US Government as Represented by the Secretary of the Army

University of Massachusetts

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Stephen Whitney

Vaniambadi Kalyanaraman

Carl R Alving

Shan Lu

Ranajit Pal

Shixia Wang

Gary R Matyas

Mangala Rao

Thomas C VanCott

Phillip Markham

Francine McCutchan

Sodsai Tovanabutra

Victoria Polonis

Eric Sanders-Buell

Mary Marovich

Tim Keen

Balachandran Nair

The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.

Truncated HIV envelope proteins (ENV), methods and compositions related thereto

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The composition and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods fro using the protein compositions as boosts following administration of the DNA compositions are provided.

Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods

Growing community of inventors

Silver Spring, MD, United States of America

Stephen Whitney