Quest Diagnostics Investments, Inc.

Stephen W Taylor

Nigel J Clarke

Richard E Reitz

Zhaohui Chen

Michael McPhaul

Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

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Laguna Niguel, CA, United States of America

Stephen W Taylor