Virginia Commonwealth University

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

US Government As Represented by the Secretary of the Army

Stephen W Rothwell

Gary L Bowlin

David Simpson

James Bowman

Thomas J Reid, Iii

Chitra Krishnamurti

David G Simpson

The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.

Electrospun dextran fibers and devices formed therefrom

Disclosed herein are wound dressings comprising fibrinogen and at least one procoagulant such as propyl gallate in a therapeutic amount. Also disclosed are methods of treating wounds, increasing an amount of or rate of coagulation of blood from a wound, increasing an amount of or rate of clot formation over a wound, increasing blood platelet counts, activating a coagulation system, increasing the plasma concentration of fibrinogen, and decreasing the activated partial thromboplastin time. Also disclosed are an arterial bleeding model and methods of studying arterial bleeding.

Fibrinogen bandages and arterial bleeding models and methods of making and using thereof

Growing community of inventors

Columbia, MD, United States of America

Stephen W Rothwell