Georgetown University

Stephen W Byers

Sivanesan Dakshanamurthy

Milton L Brown

Jaime M Guidry Auvil

Ziad Sahab

Dean Rosenthal

Provided herein are methods for treating melanoma in a subject.

Treating melanoma with mebendazole and a mitogen-activated kinase inhibitor

Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.

Predicting drug-target interactions and uses for drug repositioning and repurposing

Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

Cadherin-11 inhibitors and methods of use thereof

This invention provides for a method of preventing or treating a cadherin-11 related disease in a subject, which includes administering to the subject an effective amount of a compound of the following formula: or a pharmaceutically acceptable salt or prodrug thereof, where R, R, R, R, R, R, R, R, R, R, R, R, Xand Xare as defined herein.

Substituted pyrazines as cadherin-11 inhibitors

Small molecule inhibitors of AGBL2 are provided, as well as methods of using the inhibitors to treat or prevent cancer and neurologic disorders.

Small molecule inhibitors of AGBL2

Cadherin-11 inhibitors, including 4-(2-phenylpyridin-3-yl)phenol, and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

Growing community of inventors

Takoma Park, MD, United States of America

Stephen W Byers