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Stephen Venson O'Quinn

Roger K Cady

Donna Lee Gutterman

A method of preventing the headache phase of migraine in a human comprises administration of a 5HTreceptor agonist or administration of an over-the-counter or nonprescription drug to said human exhibiting prodrome symptoms of migraine. Suitably, the method comprises administration of a migraine headache phase-preventing effective amount of the 5HTagonist or over-the-counter or nonprescription drug. There is disclosed a preemptive prophylaxis migraine method using the following cognitive tests: Simple Reaction Time; Running Memory Continuous Performance Task; Matching to Sample; Mathematical Processing Task; and interpreting the results as a percent of baseline indicator of need for prophylaxis.

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Research Triangle Park, NC, United States of America

Stephen Venson O'Quinn