Inovio Pharmaceuticals, Inc.

Advanced Tissue Sciences, Inc.

Other

Genetronics, Inc.

Stephen V Kemmerrer

Jay R McCoy

Kate Broderick

Beat Stadelmann

Feng Lin

Rune Kjeken

Nathan Lovell

Steven Masterson

Alejandro Campillo-Agusti

Eduardo Ho

Joan Zeltinger

Dietmar P Rabussay

Charles Bankert

Mark A Applegate

Lee K Landeen

Alvin Edward Peterson

James H Flatt

Noushin Dunkelman

John W Bennett

Scott Chesla

Jason Gee

Thomas Joseph Kardos

Jerry Yaddgo

Jay Mccoy

Eduardo E Ho

The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.

Minimally invasive dermal electroporation device

A device for electroporating cells of a mammalian mucosal membrane includes a housing, an electrode microneedle plate, a voltage return electrode coupled to the housing, and an energy source. The energy source is configured to generate and deliver through the electrode microneedle plate and the voltage return electrode at least one pulse of electrical energy having an electric potential sufficient to electroporate the cells. The electrode microneedle plate is configured to provide an even distribution of a pharmaceutical formulation from the housing and to the mucosal membrane. The electrode microneedle plate includes a plurality of microneedles that are configured to contact the mucosal membrane, deliver the pharmaceutical formulation to a specific depth, and deliver the at least one pulse of ergy to the cells.

Oral mucosal electroporation device and use thereof

A jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.

Intradermal jet injection electroporation

An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly. Where the auto-lock assembly is adjustable between a locked configuration, where the shroud is not movable with respect to the body, and an unlocked configuration, where the shroud is movable with respect to the body, and where biasing the shroud from the rest position to the one or more actuated positions and back to the rest position adjusts the auto-lock from the unlocked configuration to the locked configuration.

Electroporation device with detachable needle array with lock-out system

A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

Tolerable and minimally invasive skin electroporation device

An electroporation device having a battery pack including a plurality of battery cells and at least one lead in electrical communication with a circuit board. The battery pack including a safety switch and a controller for selectively placing the battery cells in electrical communication with the one lead. Where the controller is in operable communication with the safety switch such that when the controller detects one or more operating conditions the controller instructs the safety switch to electrically isolate the lead from the battery cells. The battery pack also includes a manual switch, and where activation of the switch causes the controller to instruct the safety switch to electrically isolate the lead from the battery cells.

Electroporation device having a battery pack with power switch

The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.

Multiple tissue layer electroporation applicator and device

An jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.

Intradermal jet injection electroporation device

The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.

Miniminally invasive dermal electroporation device

This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.

Growing community of inventors

San Diego, CA, United States of America

Stephen V Kemmerrer