Ortho-mcneil Pharmaceutical Corp.

Mcneil-ppc, Inc.

Johnson & Johnson Consumer Inc.

Stephen Ulrich

Karen R Zimm

Frank J Bunick

Gerard P McNally

Vipul Bhupendra Dave

Joseph R Luber

Christopher Szymczak

Gregory E Koll

David W Wynn

Willy Maria Albert Carlo Dries

Marc Karel Jozef Francois

David B Cochran

Christopher E Szymczak

In one aspect the present invention features process for making a tablet comprising at least one pharmaceutically active agent, said method comprising the step of applying radiofrequency energy to a powder blend to sinter said powder blend into said tablet, wherein said powder blend comprises lossy coated particles and said at least one pharmaceutically active agent, wherein said lossy coated particles comprises a substrate that is at least partially coated with a lossy coating comprising at least one activator, wherein said substrate has a Q value of greater than 100 and said activator has a Q value of less than 75.

Process for making tablet using radiofrequency and lossy coated particles

The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of: (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug composition containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the powder; (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet; and (d) removing the tablet from the die cavity.

Manufacture of tablet

This invention is directed to a taste masked liquid pharmaceutical composition comprising a pharmaceutically active agent and a taste masking composition. In particular, the taste masking composition comprises a taste masking effective amount of an artificial sweetener.

Taste masked liquid pharmaceutical compositions

A taste masked pharmaceutical composition comprising a microcapsule, wherein the microcapsule comprises a pharmaceutically active agent core coated with a taste masking effective amount of a water-insoluble enteric coating, wherein the coating comprises a weakly acidic methacrylic acid-ethyl acrylate copolymer.

Taste masked pharmaceutical compositions

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Cherry Hill, NJ, United States of America

Stephen Ulrich