Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Dmw (technology) Limited

Boehringer Ingelheim Microparts Gmbh

Other

New Injection Systems Ltd.

Boehringer International Gmbh

Stephen Terence Dunne

Marc Rohrschneider

Joachim Eicher

Bernhard Freund

Wulf Bachtler

Frank Bartels

Christoph Lessmoellmann

William Barrie Hart

Jens Besseler

Johannes Geser

Terence Edward Weston

Andree Jung

Herbert Wachtel

Dieter Hochrainer

Gilbert Wuttke

Holger Holakovsky

Ralf Thoemmes

Timo Von Brunn

Achim Moser

Klaus Kadel

Joerg Schiewe

Bernd Zierenberg

Heinrich Kladders

Jessica Frentzel-Beyme

Claudius Weiler

Matthias Vehdelmann

Ralf-Peter Peters

Gert Blankenstein

Horst Wergen

Georg Boeck

Holger Reinecke

Alexander Bach

Robert Gerhard Winkler

Joachim Carl Herbert Eicher

Herbert Graessl

Thomas Sowden Reinhold

Manuel Krakowka

Ole Zumblick

Anke Klaer

Holger Hollmann

Joachin Eicher

Anthony W King

Thomas S Reinhold

Douglas Arthur Emmott

Joachim Karl Herbert Eicher

Herbert Graessel

Jörg Schiewe

A nebulizer for nebulizing a fluid from a cartridge and a cartridge for such a nebulizer is proposed. The cartridge comprises a container containing the fluid to be nebulized and is fluidically connected to the nebulizer by inserting a connecting element of the nebulizer for conveying the fluid out of the container. The cartridge is preferably adapted to sealingly receive the connecting element and can optionally comprise a membrane or sealing wall which seals the cartridge initially and is piercable or breakable by the connecting element upon insertion. The cartridge can further comprise an at least partially flexible and/or bendable tube for conveying the fluid out of the container. The tube is preferably wettable with the fluid and/or comprises an at least partially hydrophilic and/or polar surface. Further, the tube can at least partially be shaped as a helix. When the cartridge is connected to the nebulizer, the tube and the connecting element preferably form a continuous capillary and/or an at least essentially constant flow area.

Nebulizer and cartridge

Disclosed is an inhaler and a method for using the inhaler for the inhalation of a formulation from a carrier. The carrier contains the formulation in a receptacle and is set oscillating by an air current. An improved or defined delivery and nebulisation of the preferably powdered formulation is made possible by the fact that the carrier is set oscillating in defined manner, the formulation is dispensed through a cover element having three to five holes and/or the air current flows onto a fin associated with the carrier and flows past at least substantially only one flat side of the carrier.

Vibrating blister

A drug delivery device, in particular a nebulizer or inhaler, for dispensing a fluid includes a cartridge having a collapsible container within which the fluid is disposed, a mechanism to help the collapsing process and to prevent the collapsed container from expanding again, hence preventing the forming of vapor and gas bubbles within, where the mechanism is adapted to pressurize the fluid within the container during withdrawal of the fluid.

Drug delivery device

The invention relates to a system composed of an inhaler and a capsule, preferably intended for single use. The capsule contains a preferably powdered pharmaceutical preparation which, for inhalation, is expelled from the capsule through at least one hole. The capsule comprises as capsule elements a capsule cap and a capsule body, at least one of which comprises at least one prefabricated hole. The prefabricated hole in the capsule is sealed off in the transporting state of the system and is open in the usage state. The hole is exposed by actuation of a pulling mechanism. Prior to this the hole is closed off by a capsule receptacle or a film. In one embodiment the capsule may be present in two different states, for example in different insertion positions of the capsule elements. In the first state the prefabricated hole is closed off and in the second it is exposed. Also shown is an inhaler suitable as a disposable product, which is manufactured from thermoformed parts or from blister film.

System composed of inhaler and capsule

An auto-injector assembly comprises a medicament container defining a substantially cylindrical chamber containing a liquid medicament. A proximal end of the chamber is closed by a piston and a distal end of the chamber is closed by a seal spanning an opening. A biasing means, such as a spring, is coupled to the piston and acts to bias the piston towards the seal, thereby pressurizing the liquid medicament. The assembly also comprises a hypodermic needle and a removable needle cap for maintaining the hypodermic needle in sterile conditions until use. A means for establishes fluid communication between the chamber and the hypodermic needle such that the pressurized liquid medicament is automatically delivered through the hypodermic needle when communication has been established.

Auto-injector assembly

The invention relates to a capsule for receiving a preferably powdered pharmaceutical preparation and an inhaler in which, for inhalation, the preparation is expelled from the capsule through at least one hole. A capsule according to the invention comprises as capsule elements a capsule cap and a capsule body, at least one of which comprises at least one prefabricated hole. Systems according to the invention comprising inhalers and capsules are described, in which the prefabricated hole in the capsule is sealed off in the transporting state of the system and is open in the usage state. The hole is exposed by actuation of a pushing or pulling mechanism. Prior to this the hole is closed off by part of the capsule itself or by a capsule receptacle belonging to the inhaler. In one embodiment the capsule may be present in two different states, for example in different insertion positions of the capsule elements. In the first state the prefabricated hole is closed off and in the second it is exposed. Another system according to the invention consists of a capsule body open at the top and an inhaler, the capsule that is open at the top being filled inside the inhaler.

Inhalator and capsule for an inhalator

The invention relates to a dispensing device, a storage device and a method for dispensing a medical formulation. Multiple doses of the formulation are stored in a carrier having multiple storage members, each storage member containing a single dose. Each storage member comprises one duct or nozzle for dispensing the respective dose. The dispensing direction of the ducts or nozzles is directed in a lengthwise or indexing direction of the carrier. The storage device of the carrier is a peelable blister strip, wherein the ducts or nozzles can be opened one after the other by peeling the blister strip.

Dispensing device, storage device and method for dispensing a formulation

An inhaler for use with a dry powder pharmaceutical formulation, including: a chamber containing the dry powder formulation, a valve disposed in series with the chamber for regulating air flow through the chamber, and a bypass coupled around the combination of the chamber and the valve, where the valve and bypass cooperate for ensuring that the air flow is at least essentially fixed or kept constant or at a minimum accepted or desired or required flow rate through the chamber, and for varying air flow restriction through the inhaler with flow rate, or for keeping the air flow restriction generally constant.

Dry powder inhaler

The invention relates to an apparatus for nebulizing preferably powdered medicinal formulations, the nebulization being assisted by propellant. According to the invention, the propellant is supplied in pulsed form to the powder cavity () containing the formulation, which is attached to the nozzle () from which the aerosol is emitted. The apparatus according to the invention provides an increase in the fraction of pulmonary particles in the aerosol leaving the nozzle ().

Atomizer

An injector for delivering medicament comprises a collapsible container () for containing the liquid medicament, a normally-closed valve () coupled to the collapsible container () for retaining the liquid medicament within the collapsible container and an injection means () for delivering the liquid medicament from the collapsible container. The liquid medicament is maintained under pressure by a pressurizing means () which pressurizes the liquid medicament such that it is delivered by the injection means () when the normally-closed valve () is opened.

Injector

An inhaler including a pre-inserted cartridge () is proposed. The cartridge contains liquid () which is preferably pressurized to a low pressure. The cartridge is connected via an aerosol valve () with the inhaler. The liquid is further pressurized by a pump () of the inhaler to a high pressure and atomized.

Cartridge system

A dispensing device, a storage device and a method for dispensing powder in which powder is dispensed through a duct with a flat cross section to de-agglomerate the powder and to generate a spray with fine particle size. A storage chamber for the powder may be closed by a bursting element which is burst by pressurized gas for discharging the powder, the gas pressure reaching or exceeding a peak value before the bursting element bursts so that the powder is dispensed at a lower gas pressure. The powder may be forced through the duct by a gas pressure of less than 300 kPa to de-agglomerate the powder and/or to generate the spray. The storage device can have multiple storage chambers and associated ducts or nozzles, so that each dose of powder can be dispensed through a separate duct or nozzle.

Dispensing device, storage device and method for dispensing powder

A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed, which nozzle comprises two holes formed in a flat plate which plate is then deformed such that the axes of the holes intersect so that jets of fluids moving through the holes impinge with each other.

Nozzle and inhaler and method for producing a nozzle

A dispensing device, a storage device and a method for dispensing a formulation as a spray using a gas stream. Doses of the formulation are contained in storage members, which comprise individual atomizing device. The storage members are received in cavities, which are sealed by a common outlet seal. The outlet seal is peeled individually for each cavity to open the respective storage member and its atomizing device before the respective dose is dispensed by a gas stream flowing through the storage member.

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Stowmarket, United Kingdom

Stephen Terence Dunne