The Methodist Hospital

Agency for Science, Technology and Research

Nanyang Technological University

Stephen T C Wong

Hong Zhao

Joseph Sylvester Chang

Lei Zhang

Zhiping Wang

Ruige Wu

Ren Kong

Geok Soon Lim

Kemi Cui

A testing device is provided. The testing device includes a capturing tool and a microfluidic chip having a plurality of chambers connected in a network, a sample receiving port connected to the network, and a guide structure configured to receive the capturing tool, wherein the capturing tool is configured to capture sample in a distal position from the guide structure and further configured to transfer the captured sample to the sample receiving port in a proximal position from the guide structure.

Testing device, microfluidic chip and nucleic acid testing method

A method for treating a sarcoma by administering a tyrosine kinase inhibitor and a biguanide compound. Also described is a method for treating a tumor of the Ewing Sarcoma family by obtaining a tumor sample; determining in the sample gene expression levels of ACTB, B2M, MLH1, PRKDC, XPC, APEX1, ERCC5, MMS19, or RAD23; and administering a tyrosine kinase inhibitor and a biguanide compound. Furthermore, a pharmaceutical composition for treating a Ewing family tumor is disclosed. The composition contains a tyrosine kinase inhibitor, a biguanide compound, and a pharmaceutically acceptable excipient.

Compositions and methods for treating Ewing family tumors

A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or 2',4&#x2032;-dihydroxychalcone. Also disclosed is a method for treating cancer by administering a chemotherapy agent together with hesperetin, naringenin, or 2&#x2032;,4&#x2032;-dihydroxychalcone. Furthermore, a composition for treating cancer is provided, the composition containing a chemotherapy agent and hesperetin, naringenin, or 2&#x2032;,4&#x2032;-dihydroxychalcone.

Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity

Growing community of inventors

Houston, TX, United States of America

Stephen T C Wong